A preliminary animal study of thermal rheology fluid as a new temperature-dependent liquid intravascular embolic material

Purpose Thermal rheology (TR) fluid, which comprises polyethylene (PE) particles, their dispersant, and solvent, is a material that increases in viscosity to various degrees depending on the type and ratio of these constituents when its temperature rises. The viscosity of type 1 (TRF-1) increases mo...

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Bibliographic Details
Published in:Japanese journal of radiology 2022-06, Vol.40 (6), p.613-623
Main Authors: Imai, Yugo, Watanabe, Shobu, Nitta, Norihisa, Ota, Shinichi, Yao, Shigeru, Watanabe, Yoshiyuki
Format: Article
Language:English
Subjects:
Angiography
Animals
Body temperature
Constituents
Dispersants
Embolization
Embolization, Therapeutic
Humans
Imaging
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Original
Original Article
Polyethylenes
Rabbits
Radiology
Radiotherapy
Renal artery
Renal Artery - diagnostic imaging
Rheological properties
Rheology
Subgroups
Temperature
Temperature dependence
Veins & arteries
Viscosity
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Summary:Purpose Thermal rheology (TR) fluid, which comprises polyethylene (PE) particles, their dispersant, and solvent, is a material that increases in viscosity to various degrees depending on the type and ratio of these constituents when its temperature rises. The viscosity of type 1 (TRF-1) increases more than that of type 2 (TRF-2) near rabbit body temperature. This preliminary animal study aimed to determine the basic characteristics and embolic effect of TR fluid by comparing TRF-1 and TRF-2. Materials and methods Twenty-four Japanese white rabbits underwent unilateral renal artery embolization using TRF-1 or TRF-2 and follow-up angiography at 7 or 28 days (4 subgroups, n  = 6 each). Subsequently, the rabbits were euthanized, and the embolized kidneys were removed for pathological examination. The primary and final embolization rates were defined as the ratio of renal artery area not visible immediately after embolization and follow-up angiography, respectively, to visualized renal artery area before embolization. The final embolization rate and maximum vessel diameter filled with PE particles were compared between materials. Moreover, the embolic effect was determined to be persistent when a two-sided 95% confidence interval (CI) for the difference in means between the embolization rates was 
ISSN:1867-1071
1867-108X
DOI:10.1007/s11604-021-01232-3