LGG-23. Cardiac function in children and young adults treated with MEK inhibitors: a single institution retrospecive cohort study

INTRODUCTION: MEK inhibitors (MEKi) have shown efficacy in pediatric low-grade glioma, among other tumors, but have been associated with acute cardiac dysfunction in adults. Cardiac consequences in children are unknown. MATERIAL AND METHODS: We performed a single center retrospective cohort study ev...

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Bibliographic Details
Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2022-06, Vol.24 (Supplement_1), p.i92-i93
Main Authors: Robison, Nathan, Su, Jennifer, Fang, Melody, Malvar, Jemily, Menteer, Jondavid
Format: Article
Language:English
Subjects:
Low Grade Glioma
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Summary:INTRODUCTION: MEK inhibitors (MEKi) have shown efficacy in pediatric low-grade glioma, among other tumors, but have been associated with acute cardiac dysfunction in adults. Cardiac consequences in children are unknown. MATERIAL AND METHODS: We performed a single center retrospective cohort study evaluating cardiac function by echocardiography (echo) in children and young adults
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/noac079.337