Evaluation of the Association of Single Nucleotide Polymorphism rs2229238 in Interleukin 6 Receptor Alpha (IL6RA) Gene With the Risk of Preeclampsia

Introduction Many studies have gone into single nucleotide polymorphisms (SNPs) in inflammatory-associated genes and preeclampsia risk; still, the findings are inconclusive. The current study aims to evaluate the association of SNP rs2229238 in the interleukin 6 receptor alpha (IL6RA) gene with the...

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Published in:Curēus (Palo Alto, CA) CA), 2022-05, Vol.14 (5), p.e24788-e24788
Main Authors: Sivaraj, Nagarjuna, K, Vijaya Rachel, Suvvari, Tarun Kumar, Prasad, Shilaja, Sri Harsha, Boppana, Majji, Vineetha, Vegi, Pradeep Kumar, Bunga, Papa Kusuma
Format: Article
Language:English
Subjects:
Age groups
Allergy/Immunology
Alzheimer's disease
Biochemistry
Cardiovascular disease
Cytokines
Genes
Genetics
Genotype & phenotype
Gestational age
Gynecology
Hemoglobin
Hospitals
Hypertension
Maternal mortality
Medical schools
Obstetrics
Obstetrics/Gynecology
Polymorphism
Population
Preeclampsia
Pregnancy
R&D
Research & development
Womens health
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Summary:Introduction Many studies have gone into single nucleotide polymorphisms (SNPs) in inflammatory-associated genes and preeclampsia risk; still, the findings are inconclusive. The current study aims to evaluate the association of SNP rs2229238 in the interleukin 6 receptor alpha (IL6RA) gene with the risk of preeclampsia. Methodology An observational case-control study was conducted and 216 patients were included in this study. Of the patients, 104 were normotensive subjects and 112 were subjects with preeclampsia. Genotyping for SNP rs2229238 was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results The genotype allocation of the SNP 2229238 C/A polymorphism was not different in preeclampsia subjects (CC: 42%; CA: 42%; AA: 16%) and normotensive pregnant women (CC: 37%; CA: 48%; AA: 15%) (p-value = 0.73). The frequency of the A allele was 34% in preeclampsia subjects and 31% in normotensive pregnancies. There was no significant variation seen in the allele frequencies among cases and the control population. Conclusion Our study reported that there is no significant relation between preeclampsia and IL6RA SNP rs2229238. Also, there is no significance in the allele frequencies among both cases and control groups.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.24788