Review of evidence for environmental causes of uveal coloboma

Uveal coloboma is a condition defined by missing ocular tissues and is a significant cause of childhood blindness. It occurs from a failure of the optic fissure to close during embryonic development and may lead to missing parts of the iris, ciliary body, retina, choroid, and optic nerve. Because th...

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Bibliographic Details
Published in:Survey of ophthalmology 2022-07, Vol.67 (4), p.1031-1047
Main Authors: Selzer, Evan B., Blain, Delphine, Hufnagel, Robert B., Lupo, Philip J., Mitchell, Laura E., Brooks, Brian P.
Format: Article
Language:English
Subjects:
Anophthalmia
Choroid
Coloboma
Coloboma - genetics
Developmental Eye Defects
Environmental Causes
Female
Humans
Microphthalmia
Ocular Teratogens
Pregnancy
Retina
Uveal Coloboma
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Summary:Uveal coloboma is a condition defined by missing ocular tissues and is a significant cause of childhood blindness. It occurs from a failure of the optic fissure to close during embryonic development and may lead to missing parts of the iris, ciliary body, retina, choroid, and optic nerve. Because there is no treatment for coloboma, efforts have focused on prevention. While several genetic causes of coloboma have been identified, little definitive research exists regarding the environmental causes of this condition. We review the current literature on environmental factors associated with coloboma in an effort to guide future research and preventative counseling related to this condition.
ISSN:0039-6257
1879-3304
DOI:10.1016/j.survophthal.2021.12.008