Association of serum hepatoma‐derived growth factor levels with disease activity in rheumatoid arthritis: A pilot study

Background Hepatoma‐derived growth factor (HDGF) is reported to play an important role in tumorigenesis and cancer progression. However, growing evidence indicates its participation in immune system activation. This study analyzed the relationship among serum HDGF levels, disease activity, and labor...

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Bibliographic Details
Published in:Journal of clinical laboratory analysis 2022-06, Vol.36 (6), p.e24474-n/a
Main Authors: Ahn, Sung Soo, Kim, Hye Min, Park, Younhee
Format: Article
Language:English
Subjects:
Adult
Age
alarmin
Arthritis, Rheumatoid
biomarker
Biomarkers
Blood
Blood platelets
Blood Sedimentation
Confidence intervals
Correlation analysis
Cytokines
disease activity
Erythrocyte sedimentation rate
Growth factors
Hepatoma
hepatoma‐derived growth factor
Humans
Immune system
Intercellular Signaling Peptides and Proteins
Laboratories
Liver cancer
Lung diseases
Osteoarthritis
Patients
Phosphatase
Pilot Projects
Proteins
Remission
Remission (Medicine)
Rheumatoid arthritis
Rheumatoid Factor
Rheumatology
Software
Tumorigenesis
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Summary:Background Hepatoma‐derived growth factor (HDGF) is reported to play an important role in tumorigenesis and cancer progression. However, growing evidence indicates its participation in immune system activation. This study analyzed the relationship among serum HDGF levels, disease activity, and laboratory markers in patients with rheumatoid arthritis (RA). Methods Blood samples from 165 patients with RA, 42 with osteoarthritis (OA), and 28 healthy controls, were used to evaluate the serum HDGF levels. Correlations of serum HDGF levels with age, 28‐joint count disease activity score (DAS28), and laboratory findings were assessed by Pearson correlation and receiver operator characteristic (ROC) curve analyses to obtain HDGF optimal cutoffs according to the disease status. Immunohistochemical staining was performed on the knee synovial tissue samples from patients with RA and OA (n = 10 each) to investigate HDGF joint expression. Results Serum HDGF levels were significantly correlated with DAS28 erythrocyte sedimentation rate (r = 0.412, p 
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.24474