Association between age and disease specific mortality in medullary thyroid cancer

The aim of this study was to evaluate the association between age and disease specific mortality (DSM) among adults diagnosed with medullary thyroid cancer (MTC). Surveillance, Epidemiology, and End Results (SEER-18) was used to analyze adult MTC patients stratified by age (18–64, 65–79, ≥80 years)....

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Bibliographic Details
Published in:The American journal of surgery 2021-02, Vol.221 (2), p.478-484
Main Authors: Sahli, Zeyad T., Canner, Joseph K., Zeiger, Martha A., Mathur, Aarti
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Age
Age Factors
Age groups
Aged
Aged, 80 and over
Aging
Cancer
Carcinoma, Neuroendocrine - diagnosis
Carcinoma, Neuroendocrine - mortality
Carcinoma, Neuroendocrine - surgery
Demographics
Demography
Disease
Disease-specific mortality
Elderly
Epidemiology
Female
Gender
Hispanic Americans
Humans
Lymphatic system
Male
Medical prognosis
Medullary thyroid cancer
Metastases
Metastasis
Middle Aged
Mortality
Neoplasm Staging
Older adults
Older people
Patients
Prognosis
Regression analysis
Retrospective Studies
SEER Program - statistics & numerical data
Surgery
Survival
Survival analysis
Thyroid
Thyroid cancer
Thyroid Gland - pathology
Thyroid Gland - surgery
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - mortality
Thyroid Neoplasms - surgery
Thyroidectomy
Treatment Outcome
United States - epidemiology
Young Adult
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Summary:The aim of this study was to evaluate the association between age and disease specific mortality (DSM) among adults diagnosed with medullary thyroid cancer (MTC). Surveillance, Epidemiology, and End Results (SEER-18) was used to analyze adult MTC patients stratified by age (18–64, 65–79, ≥80 years). Associations between patient demographics, tumor size, nodal status, metastatic disease, and extent of surgery on DSM was assessed with multivariable Cox regression. Among 1457 patients with MTC, 1008 (69.2%) were younger adults, 371 (25.5%) older adults, and 78 (5.4%) were super-elderly. A significantly higher proportion of older adults and super-elderly had less than the recommended operation for MTC. On multivariable analysis, older adults and super-elderly were 2.9 and 6.7 times more likely to have an increased DSM (HR:2.91, 95% CI: 1.83–4.63; p 
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2020.09.025