Association between age and disease specific mortality in medullary thyroid cancer

The aim of this study was to evaluate the association between age and disease specific mortality (DSM) among adults diagnosed with medullary thyroid cancer (MTC). Surveillance, Epidemiology, and End Results (SEER-18) was used to analyze adult MTC patients stratified by age (18–64, 65–79, ≥80 years)....

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Published in:The American journal of surgery 2021-02, Vol.221 (2), p.478-484
Main Authors: Sahli, Zeyad T., Canner, Joseph K., Zeiger, Martha A., Mathur, Aarti
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Age
Age Factors
Age groups
Aged
Aged, 80 and over
Aging
Cancer
Carcinoma, Neuroendocrine - diagnosis
Carcinoma, Neuroendocrine - mortality
Carcinoma, Neuroendocrine - surgery
Demographics
Demography
Disease
Disease-specific mortality
Elderly
Epidemiology
Female
Gender
Hispanic Americans
Humans
Lymphatic system
Male
Medical prognosis
Medullary thyroid cancer
Metastases
Metastasis
Middle Aged
Mortality
Neoplasm Staging
Older adults
Older people
Patients
Prognosis
Regression analysis
Retrospective Studies
SEER Program - statistics & numerical data
Surgery
Survival
Survival analysis
Thyroid
Thyroid cancer
Thyroid Gland - pathology
Thyroid Gland - surgery
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - mortality
Thyroid Neoplasms - surgery
Thyroidectomy
Treatment Outcome
United States - epidemiology
Young Adult
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creator Sahli, Zeyad T.
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description The aim of this study was to evaluate the association between age and disease specific mortality (DSM) among adults diagnosed with medullary thyroid cancer (MTC). Surveillance, Epidemiology, and End Results (SEER-18) was used to analyze adult MTC patients stratified by age (18–64, 65–79, ≥80 years). Associations between patient demographics, tumor size, nodal status, metastatic disease, and extent of surgery on DSM was assessed with multivariable Cox regression. Among 1457 patients with MTC, 1008 (69.2%) were younger adults, 371 (25.5%) older adults, and 78 (5.4%) were super-elderly. A significantly higher proportion of older adults and super-elderly had less than the recommended operation for MTC. On multivariable analysis, older adults and super-elderly were 2.9 and 6.7 times more likely to have an increased DSM (HR:2.91, 95% CI: 1.83–4.63; p 
doi_str_mv 10.1016/j.amjsurg.2020.09.025
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Surveillance, Epidemiology, and End Results (SEER-18) was used to analyze adult MTC patients stratified by age (18–64, 65–79, ≥80 years). Associations between patient demographics, tumor size, nodal status, metastatic disease, and extent of surgery on DSM was assessed with multivariable Cox regression. Among 1457 patients with MTC, 1008 (69.2%) were younger adults, 371 (25.5%) older adults, and 78 (5.4%) were super-elderly. A significantly higher proportion of older adults and super-elderly had less than the recommended operation for MTC. On multivariable analysis, older adults and super-elderly were 2.9 and 6.7 times more likely to have an increased DSM (HR:2.91, 95% CI: 1.83–4.63; p &lt; 0.001 and HR: 6.70, 95%CI: 3.69–12.20; p &lt; 0.001). Extent of surgery or lymphadenectomy did not affect DSM. Increased age is an independent predictor of DSM in patients with MTC. •Older adults had less than the initial recommended operation for medullary thyroid cancer (MTC).•Extent of surgery or lymphadenectomy did not affect disease-specific mortality in patients with MTC.•Increased age was an independent predictor of DSM.•African American race was associated with increased DSM.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2020.09.025</identifier><identifier>PMID: 33010878</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Adults ; Age ; Age Factors ; Age groups ; Aged ; Aged, 80 and over ; Aging ; Cancer ; Carcinoma, Neuroendocrine - diagnosis ; Carcinoma, Neuroendocrine - mortality ; Carcinoma, Neuroendocrine - surgery ; Demographics ; Demography ; Disease ; Disease-specific mortality ; Elderly ; Epidemiology ; Female ; Gender ; Hispanic Americans ; Humans ; Lymphatic system ; Male ; Medical prognosis ; Medullary thyroid cancer ; Metastases ; Metastasis ; Middle Aged ; Mortality ; Neoplasm Staging ; Older adults ; Older people ; Patients ; Prognosis ; Regression analysis ; Retrospective Studies ; SEER Program - statistics &amp; numerical data ; Surgery ; Survival ; Survival analysis ; Thyroid ; Thyroid cancer ; Thyroid Gland - pathology ; Thyroid Gland - surgery ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - mortality ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Treatment Outcome ; United States - epidemiology ; Young Adult</subject><ispartof>The American journal of surgery, 2021-02, Vol.221 (2), p.478-484</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. 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Surveillance, Epidemiology, and End Results (SEER-18) was used to analyze adult MTC patients stratified by age (18–64, 65–79, ≥80 years). Associations between patient demographics, tumor size, nodal status, metastatic disease, and extent of surgery on DSM was assessed with multivariable Cox regression. Among 1457 patients with MTC, 1008 (69.2%) were younger adults, 371 (25.5%) older adults, and 78 (5.4%) were super-elderly. A significantly higher proportion of older adults and super-elderly had less than the recommended operation for MTC. On multivariable analysis, older adults and super-elderly were 2.9 and 6.7 times more likely to have an increased DSM (HR:2.91, 95% CI: 1.83–4.63; p &lt; 0.001 and HR: 6.70, 95%CI: 3.69–12.20; p &lt; 0.001). Extent of surgery or lymphadenectomy did not affect DSM. Increased age is an independent predictor of DSM in patients with MTC. •Older adults had less than the initial recommended operation for medullary thyroid cancer (MTC).•Extent of surgery or lymphadenectomy did not affect disease-specific mortality in patients with MTC.•Increased age was an independent predictor of DSM.•African American race was associated with increased DSM.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Age Factors</subject><subject>Age groups</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Cancer</subject><subject>Carcinoma, Neuroendocrine - diagnosis</subject><subject>Carcinoma, Neuroendocrine - mortality</subject><subject>Carcinoma, Neuroendocrine - surgery</subject><subject>Demographics</subject><subject>Demography</subject><subject>Disease</subject><subject>Disease-specific mortality</subject><subject>Elderly</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gender</subject><subject>Hispanic Americans</subject><subject>Humans</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medullary thyroid cancer</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasm Staging</subject><subject>Older adults</subject><subject>Older people</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>SEER Program - statistics &amp; 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numerical data</topic><topic>Surgery</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Gland - surgery</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - mortality</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Treatment Outcome</topic><topic>United States - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahli, Zeyad T.</creatorcontrib><creatorcontrib>Canner, Joseph K.</creatorcontrib><creatorcontrib>Zeiger, Martha A.</creatorcontrib><creatorcontrib>Mathur, Aarti</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest - Health &amp; 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Surveillance, Epidemiology, and End Results (SEER-18) was used to analyze adult MTC patients stratified by age (18–64, 65–79, ≥80 years). Associations between patient demographics, tumor size, nodal status, metastatic disease, and extent of surgery on DSM was assessed with multivariable Cox regression. Among 1457 patients with MTC, 1008 (69.2%) were younger adults, 371 (25.5%) older adults, and 78 (5.4%) were super-elderly. A significantly higher proportion of older adults and super-elderly had less than the recommended operation for MTC. On multivariable analysis, older adults and super-elderly were 2.9 and 6.7 times more likely to have an increased DSM (HR:2.91, 95% CI: 1.83–4.63; p &lt; 0.001 and HR: 6.70, 95%CI: 3.69–12.20; p &lt; 0.001). Extent of surgery or lymphadenectomy did not affect DSM. Increased age is an independent predictor of DSM in patients with MTC. •Older adults had less than the initial recommended operation for medullary thyroid cancer (MTC).•Extent of surgery or lymphadenectomy did not affect disease-specific mortality in patients with MTC.•Increased age was an independent predictor of DSM.•African American race was associated with increased DSM.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33010878</pmid><doi>10.1016/j.amjsurg.2020.09.025</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0428-8526</orcidid><oa>free_for_read</oa></addata></record>
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source ScienceDirect Freedom Collection 2022-2024
subjects Adolescent
Adult
Adults
Age
Age Factors
Age groups
Aged
Aged, 80 and over
Aging
Cancer
Carcinoma, Neuroendocrine - diagnosis
Carcinoma, Neuroendocrine - mortality
Carcinoma, Neuroendocrine - surgery
Demographics
Demography
Disease
Disease-specific mortality
Elderly
Epidemiology
Female
Gender
Hispanic Americans
Humans
Lymphatic system
Male
Medical prognosis
Medullary thyroid cancer
Metastases
Metastasis
Middle Aged
Mortality
Neoplasm Staging
Older adults
Older people
Patients
Prognosis
Regression analysis
Retrospective Studies
SEER Program - statistics & numerical data
Surgery
Survival
Survival analysis
Thyroid
Thyroid cancer
Thyroid Gland - pathology
Thyroid Gland - surgery
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - mortality
Thyroid Neoplasms - surgery
Thyroidectomy
Treatment Outcome
United States - epidemiology
Young Adult
title Association between age and disease specific mortality in medullary thyroid cancer
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