IgA vasculitis with severe renal manifestation

IgA vasculitis is a rare systemic vasculitis in adults, frequently more severe than in paediatric age. It manifests with cutaneous, articular, gastrointestinal and renal involvement.We present a case of a man in his 40s diagnosed with IgA vasculitis with cutaneous, joint, gastrointestinal and renal...

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Bibliographic Details
Published in:BMJ case reports 2022-06, Vol.15 (6), p.e248686
Main Authors: Marques Dias, Joana, Ferreira, Marta Azevedo, Grilo, Ana, Gonçalves, Fernando Martos
Format: Article
Language:English
Subjects:
Abdomen
Adult
Antibodies
Biopsy
Blood pressure
Case reports
Case Reports: Unusual presentation of more common disease/injury
Child
Classification
Creatinine
Cyclophosphamide - therapeutic use
Edema
Glomerulonephritis, IGA - complications
Glomerulonephritis, IGA - diagnosis
Glomerulonephritis, IGA - drug therapy
Glomerulonephritis, Membranoproliferative - pathology
Hematuria
Hemoglobin
Humans
Hypertension
IgA Vasculitis - complications
IgA Vasculitis - diagnosis
IgA Vasculitis - drug therapy
Kidney - pathology
Male
Medical prognosis
Pediatrics
Rheumatology
Urine
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Summary:IgA vasculitis is a rare systemic vasculitis in adults, frequently more severe than in paediatric age. It manifests with cutaneous, articular, gastrointestinal and renal involvement.We present a case of a man in his 40s diagnosed with IgA vasculitis with cutaneous, joint, gastrointestinal and renal disease. Significant proteinuria and renal biopsy findings demonstrating crescentic glomerulonephritis led to the onset of early immunosuppression with corticoid and cyclophosphamide. This case report reflects a case of more severe renal impairment due to IgA vasculitis with good outcome with the chosen therapy. The findings in the renal biopsy after treatment supported the good response to the chosen immunosuppression.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2021-248686