Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder

Valerian extract capsule (VEC) is an effective Chinese patent medicine used for gastrointestinal (GI) diseases. To investigate the detailed pharmacological activity for VEC clinical effects in GI diseases. Sprague-Dawley rats were divided into six groups: control, model, and drug-treated (VEC-L, VEC...

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Bibliographic Details
Published in:Pharmaceutical biology 2022-12, Vol.60 (1), p.1095-1105
Main Authors: Feng, Yuan, Dai, Wan, Ke, Junyu, Cui, Yong, Li, Shuang, Ma, Jingjing, Guo, Wenfeng, Chen, Gang, Li, Ning, Li, Yanwu
Format: Article
Language:English
Subjects:
Animals
Anti-Ulcer Agents - pharmacology
Epinephrine
Epinephrine - adverse effects
Ethanol
Ethanol - toxicity
Gastric motility
Gastric Mucosa
Gastrointestinal diseases
Gastrointestinal Motility
Indomethacin
Indomethacin - toxicity
Inflammation
Intestinal motility
Intestine
Mice
Mice, Inbred C57BL
Motility
Muscle contraction
Neostigmine
Neostigmine - adverse effects
Oral administration
Oxidative stress
Plant Extracts - adverse effects
Rabbits
Rats
Rats, Sprague-Dawley
small intestinal motility
Smooth muscle
smooth muscle relaxation
Stomach Ulcer - chemically induced
valepotriates
Valerian
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Summary:Valerian extract capsule (VEC) is an effective Chinese patent medicine used for gastrointestinal (GI) diseases. To investigate the detailed pharmacological activity for VEC clinical effects in GI diseases. Sprague-Dawley rats were divided into six groups: control, model, and drug-treated (VEC-L, VEC-M, VEC-H, and teprenone). Rats were orally administered VEC (124, 248, 496 mg/kg) and teprenone (21.43 mg/kg) for 3 consecutive days. After 1 h, the five groups (except the control group) were orally given ethanol (10 mL/kg) for 1 h or indomethacin (80 mg/kg) for 7 h. The spasmolytic activity of VEC (0.01-1 mg/mL) on ACh/BaCl 2 -induced New Zealand rabbit smooth muscle contraction was performed. The C57BL/6 mice carbon propelling test evaluated the effects of VEC (248-992 mg/kg) on intestinal motility in normal and neostigmine/adrenaline-induced mice. Compared with the model group, VEC treatment reduced the gastric lesion index and mucosal damage. Further experiments showed that the pathological ameliorative effect of VEC was accompanied by augmentation of the enzymatic antioxidant system and cytoprotective marker (COX-1, p 
ISSN:1388-0209
1744-5116
DOI:10.1080/13880209.2022.2071449