Loading…

The role of ipRGCs in ocular growth and myopia development

The increasing global prevalence of myopia calls for elaboration of the pathogenesis of this disease. Here, we show that selective ablation and activation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in developing mice induced myopic and hyperopic refractive shifts by modulating t...

Full description

Saved in:
Bibliographic Details
Published in:Science advances 2022-06, Vol.8 (23), p.eabm9027-eabm9027
Main Authors: Liu, Ai-Lin, Liu, Yun-Feng, Wang, Ge, Shao, Yu-Qi, Yu, Chen-Xi, Yang, Zhe, Zhou, Zi-Rui, Han, Xu, Gong, Xue, Qian, Kang-Wei, Wang, Li-Qin, Ma, Yuan-Yuan, Zhong, Yong-Mei, Weng, Shi-Jun, Yang, Xiong-Li
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The increasing global prevalence of myopia calls for elaboration of the pathogenesis of this disease. Here, we show that selective ablation and activation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in developing mice induced myopic and hyperopic refractive shifts by modulating the corneal radius of curvature (CRC) and axial length (AL) in an opposite way. Melanopsin- and rod/cone-driven signals of ipRGCs were found to influence refractive development by affecting the AL and CRC, respectively. The role of ipRGCs in myopia progression is evidenced by attenuated form-deprivation myopia magnitudes in ipRGC-ablated and melanopsin-deficient animals and by enhanced melanopsin expression/photoresponses in form-deprived eyes. Cell subtype-specific ablation showed that M1 subtype cells, and probably M2/M3 subtype cells, are involved in ocular development. Thus, ipRGCs contribute substantially to mouse eye growth and myopia development, which may inspire novel strategies for myopia intervention.
ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.abm9027