Acute Meningoencephalitis after COVID-19 Vaccination in an Adult Patient with Rheumatoid Vasculitis

We herein report a 72-year-old woman with rheumatoid vasculitis who exhibited a depressed level of consciousness after receiving the first dose of the Pfizer-BioNTech mRNA BNT162b COVID-19 vaccine and was diagnosed with meningoencephalitis. Although there was no confirmatory examination, the diagnos...

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Bibliographic Details
Published in:Internal Medicine 2022/05/15, Vol.61(10), pp.1609-1612
Main Authors: Senda, Joe, Ashida, Ryosei, Sugawara, Kyoko, Kawaguchi, Katsuhiro
Format: Article
Language:English
Subjects:
Adult
Aged
BNT162 Vaccine
Case Report
COVID-19 - complications
COVID-19 vaccines
COVID-19 Vaccines - adverse effects
Female
Humans
Internal medicine
Intravenous administration
Magnetic resonance imaging
Meningoencephalitis
Meningoencephalitis - diagnosis
Meningoencephalitis - etiology
mRNA
Neurological complications
Pfizer-BioNTech mRNA BNT162b COVID-19 postvaccination
Rheumatoid Vasculitis - etiology
Vaccination
Vaccination - adverse effects
Vasculitis
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Summary:We herein report a 72-year-old woman with rheumatoid vasculitis who exhibited a depressed level of consciousness after receiving the first dose of the Pfizer-BioNTech mRNA BNT162b COVID-19 vaccine and was diagnosed with meningoencephalitis. Although there was no confirmatory examination, the diagnosis was based on magnetic resonance imaging (MRI) findings and etiological assessments, including microbiological and autoimmune investigations. Both intravenous steroid pulse and gammaglobulin therapies alleviated the patient's symptoms, and the MRI findings improved. Although the efficacy of COVID-19 vaccination has been widely accepted, such neurologic complications might occur in patients with rheumatoid diseases or vasculitis syndromes.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.8815-21