CV2/CRMP5-antibody-related Paraneoplastic Neurologic Syndrome Associated with Gastrointestinal Stromal Tumor

Paraneoplastic neurological syndrome (PNS) is a heterogeneous group of neurological disorders caused by immune-mediated inflammatory mechanisms. We herein report a 77-year-old man with CV2/CRMP5-antibody-related PNS associated with a gastrointestinal stromal tumor (GIST). He was admitted for forgetf...

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Bibliographic Details
Published in:Internal Medicine 2022/05/15, Vol.61(10), pp.1497-1501
Main Authors: Fukushima, Hirofumi, Shibuya, Tomoyoshi, Awatsu, Takahito, Kurosawa, Taro, Haga, Keiichi, Murakami, Takashi, Serizawa, Nobuko, Mori, Akio, Hojo, Mariko, Yao, Takashi, Hattori, Nobutaka, Nagahara, Akihito
Format: Article
Language:English
Subjects:
Antibodies
Case Report
CV2/CRMP5 antibodies
developed limbic encephalitis
Gastrectomy
gastrointestinal stromal tumor
Inflammation
Internal medicine
Mediator protein
Neurological diseases
paraneoplastic neurologic syndrome
Serology
Tumors
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Summary:Paraneoplastic neurological syndrome (PNS) is a heterogeneous group of neurological disorders caused by immune-mediated inflammatory mechanisms. We herein report a 77-year-old man with CV2/CRMP5-antibody-related PNS associated with a gastrointestinal stromal tumor (GIST). He was admitted for forgetfulness and delusional behavior. His neurological symptoms were subacute, and a whole-body examination revealed a gastric GIST. Serology showed CV2/collapsin response mediator protein (CRMP)-5 antibodies. Partial gastrectomy was performed for the GIST, and the neurological symptoms and serum CV2/CRMP5 antibodies disappeared. No relapse has occurred since the surgery. PNS should be considered in patients with subacute neurological disorders.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.8425-21