Secreted miR-153 Controls Proliferation and Invasion of Higher Gleason Score Prostate Cancer

Prostate cancer (PC) is a male common neoplasm and is the second leading cause of cancer death in American men. PC is traditionally diagnosed by the evaluation of prostate secreted antigen (PSA) in the blood. Due to the high levels of false positives, digital rectal examination and transrectal ultra...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-06, Vol.23 (11), p.6339
Main Authors: Bertoli, Gloria, Panio, Antonella, Cava, Claudia, Gallivanone, Francesca, Alini, Martina, Strano, Giulia, Molfino, Federico, Brioschi, Loredana, Viani, Paola, Porro, Danilo
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Cell growth
Cell proliferation
Cell Proliferation - genetics
Diagnosis
Exosomes
Gene expression
Humans
Krueppel-like factor
Magnetic resonance imaging
Male
Metastasis
Microenvironments
MicroRNAs
MicroRNAs - genetics
Mortality
Neoplasia
Neoplasm Grading
Prostate cancer
Prostate-Specific Antigen
Prostatic Neoplasms - metabolism
Surveillance
Tumor Microenvironment
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Summary:Prostate cancer (PC) is a male common neoplasm and is the second leading cause of cancer death in American men. PC is traditionally diagnosed by the evaluation of prostate secreted antigen (PSA) in the blood. Due to the high levels of false positives, digital rectal examination and transrectal ultrasound guided biopsy are necessary in uncertain cases with elevated PSA levels. Nevertheless, the high mortality rate suggests that new PC biomarkers are urgently needed to help clinical diagnosis. In a previous study, we have identified a network of genes, altered in high Gleason Score (GS) PC (GS ≥ 7), being regulated by miR-153. Until now, no publication has explained the mechanism of action of miR-153 in PC. By in vitro studies, we found that the overexpression of miR-153 in high GS cell lines is required to control cell proliferation, migration and invasion rates, targeting Kruppel-like factor 5 ( ). Moreover, miR-153 could be secreted by exosomes and microvesicles in the microenvironment and, once entered into the surrounding tissue, could influence cellular growth. Being upregulated in high GS human PC, miR-153 could be proposed as a circulating biomarker for PC diagnosis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23116339