Risk factors for lumbosacral radiculoplexus neuropathy

• Published in: Muscle & nerve 2022-05, Vol.65 (5), p.593-598
• Main Authors: Pinto, Marcus V., Ng, Peng‐Soon, Laughlin, Ruple S., Thapa, Prabin, Aragon Pinto, Catarina, Shelly, Shahar, Shouman, Kamal, Dyck, Peter J., Dyck, P. James B.
• Format: Article
• Language: English
• Subjects: Autoimmune Diseases; Body mass; Body mass index; Body size; Comorbidity; Confidence intervals; Dementia disorders; Demographic variables; Diabetes mellitus; Diabetic Neuropathies; Diabetic neuropathy; Dyslipidemia; Epidemiology; Humans; Hypertension; lumbosacral plexopathy; Lumbosacral Plexus; lumbosacral radiculoplexus neuropathy; Metabolism; Multivariate analysis; Patients; Performance prediction; Regression analysis; Risk analysis; Risk Factors; Statistical analysis; Stroke; vasculitis
• ISSN: 0148-639X; 1097-4598
• DOI: 10.1002/mus.27484

Introduction/Aims Recently, our group found an association between diabetes mellitus (DM) and lumbosacral radiculoplexus neuropathy (LRPN) in Olmsted County, Minnesota; we found a higher risk (odds ratio [OR], 7.91) for developing LRPN in diabetic compared with nondiabetic patients. However, the influence of other comorbidities and anthropomorphic variables was not studied. Methods Demographic and clinical data from 59 LRPN patients and 177 age/sex‐matched controls were extracted using the Rochester LRPN epidemiological study. Differences between groups were compared by chi‐square/Fisher exact test or Wilcoxon rank‐sum test. Uni‐ and multivariate logistic regression analysis were performed. Results Factors predictive of LRPN on univariate analysis were DM (OR, 7.91; 95% confidence interval [CI], 4.11‐15.21), dementia (OR, 6.36; 95% CI, 1.13‐35.67), stroke (OR, 3.81; 95% CI, 1.32‐11.01), dyslipidemia (OR, 2.844; 95% CI, 1.53‐5.27), comorbid autoimmune disorders (OR, 2.72; 95% CI, 1.07‐6.93), hypertension (OR, 2.25; 95% CI, 1.2‐4.13), obesity (OR, 2.05; 95% CI, 1.11–3.8), body mass index (BMI) (OR, 1.1; 95% CI, 1.04‐1.15), and weight (OR, 1.02; 95% CI, 1.009‐1.037). On multivariate logistic regression analysis only DM (OR, 8.03; 95% CI, 3.86‐16.7), comorbid autoimmune disorders (OR, 4.58; 95% CI, 1.45‐14.7), stroke (OR, 4.13; 95% CI, 1.2‐14.25), and BMI (OR, 1.07; 95% CI, 1.01‐1.13) were risk factors for LRPN. Discussion DM is the strongest risk factor for the development of LRPN, followed by comorbid autoimmune disorders, stroke, and higher BMI. Altered metabolism and immune dysfunction seem to be the most influential factors in the development of LRPN.