Progressive Global Ataxia With Sensory Changes as a Paraneoplastic Syndrome in a Patient With Chromophobe Renal Cell Carcinoma

Paraneoplastic syndromes (PNS) are rare and can be challenging to diagnose and treat. The uniqueness of PNS lies in the complexity of presentation, the importance of early diagnosis, and the role of multidisciplinary care in managing those patients to mitigate long-term neurologic complications. We...

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Published in:Curēus (Palo Alto, CA) CA), 2022-05, Vol.14 (5), p.e24913
Main Authors: Basree, Mustafa M, Rudy, Raquel, Romaniello, Cristina, Smith, Daniel E, Kander, Elizabeth
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Antibodies
Ataxia
Autoimmune diseases
Case reports
Coronaviruses
COVID-19 vaccines
Diplopia
Electromyography
Guillain-Barre syndrome
Hypercalcemia
Internal Medicine
Kidney cancer
Lymphatic system
Magnetic resonance imaging
Metastasis
Motor neurone disease
Nervous system
Neurology
Occupational therapy
Oncology
Patients
Peripheral neuropathy
Tumors
Urinary retention
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creator Basree, Mustafa M
Rudy, Raquel
Romaniello, Cristina
Smith, Daniel E
Kander, Elizabeth
description Paraneoplastic syndromes (PNS) are rare and can be challenging to diagnose and treat. The uniqueness of PNS lies in the complexity of presentation, the importance of early diagnosis, and the role of multidisciplinary care in managing those patients to mitigate long-term neurologic complications. We describe a patient with metastatic renal cell carcinoma who presented with a complex constellation of neurological symptoms (progressive global ataxia and sensory changes) that did not resolve following nephrectomy. While complete resolution of symptoms was not achieved, he did have stabilization of his neurologic decline with the initiation of cancer-directed therapies.
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subjects Amyotrophic lateral sclerosis
Antibodies
Ataxia
Autoimmune diseases
Case reports
Coronaviruses
COVID-19 vaccines
Diplopia
Electromyography
Guillain-Barre syndrome
Hypercalcemia
Internal Medicine
Kidney cancer
Lymphatic system
Magnetic resonance imaging
Metastasis
Motor neurone disease
Nervous system
Neurology
Occupational therapy
Oncology
Patients
Peripheral neuropathy
Tumors
Urinary retention
title Progressive Global Ataxia With Sensory Changes as a Paraneoplastic Syndrome in a Patient With Chromophobe Renal Cell Carcinoma
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