Primary Extra-Osseous Ewing Sarcoma of the Thyroid: A Case Report and Review of the Literature

Extra-osseous Ewing sarcoma (ES) is a rare and aggressive malignant tumor found in a variety of organs. Primary ES of the thyroid is exceedingly rare and few cases have been documented to date. We describe the case of a 54-year old woman with a history of breast carcinoma in whom a unique hypermetab...

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Bibliographic Details
Published in:Head & neck pathology (Totowa, N.J.) N.J.), 2022-06, Vol.16 (2), p.581-586
Main Authors: Seipel, Amanda H., Mechahougui, Hiba, Mach, Nicolas, Triponez, Frédéric, Faquin, William C., De Vito, Claudio
Format: Article
Language:English
Subjects:
Case Reports
Dentistry
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Otorhinolaryngology
Pathology
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Summary:Extra-osseous Ewing sarcoma (ES) is a rare and aggressive malignant tumor found in a variety of organs. Primary ES of the thyroid is exceedingly rare and few cases have been documented to date. We describe the case of a 54-year old woman with a history of breast carcinoma in whom a unique hypermetabolic left thyroid nodule was identified during a follow-up PET-CT scan. An ultrasound examination showed a hypoechogenic nodule of 3.7 cm. A cytological diagnosis of poorly differentiated thyroid carcinoma was made, and a total thyroidectomy was performed. The surgical specimen revealed a poorly differentiated neoplasm composed of medium-sized cells with scant cytoplasm, expressing pancytokeratin, CD99 and NKX2.2 but lacking p63 and p40 expression. Molecular analysis revealed a EWSR1-FLI1 fusion transcript supporting the diagnosis of a primary extra-osseous ES of the thyroid. The patient received adjuvant chemotherapy and has no evidence of recurrent disease.
ISSN:1936-0568
1936-055X
1936-0568
DOI:10.1007/s12105-021-01365-x