Cip1 tunes cell cycle arrest duration upon calcineurin activation

SignificanceTo ensure their survival, cells arrest the cell division cycle when they are exposed to environmental stress. The duration of this arrest is dependent upon the time it takes a cell to adapt to a particular environment. How cells adjust the amount of time they remain arrested is not known...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2022-06, Vol.119 (23), p.e2202469119-e2202469119
Main Authors: Flynn, Mackenzie J, Benanti, Jennifer A
Format: Article
Language:English
Subjects:
Biological Sciences
Calcineurin
Calcineurin - metabolism
Cell activation
Cell cycle
Cell Cycle - physiology
Cell Cycle Checkpoints
Cell Cycle Proteins - metabolism
Cellular stress response
Cyclin-Dependent Kinase Inhibitor p21 - metabolism
Environmental stress
Enzyme inhibitors
Gene regulation
Hog1 protein
Kinases
Phosphorylation
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
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Summary:SignificanceTo ensure their survival, cells arrest the cell division cycle when they are exposed to environmental stress. The duration of this arrest is dependent upon the time it takes a cell to adapt to a particular environment. How cells adjust the amount of time they remain arrested is not known. This study investigates the role of the phosphatase calcineurin in controlling cell cycle arrest duration in yeast. We show that calcineurin lengthens arrest by prolonging Hog1-dependent activation of the poorly characterized cyclin-dependent kinase inhibitor Cip1. Cip1 only impacts cell cycle arrest in response to stressors that robustly activate calcineurin, suggesting that Cip1 is a context-specific regulator that differentially adjusts the length of arrest depending on the particular stressor.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2202469119