Inflammation on bronchoalveolar lavage cytology is associated with decreased chronic lung allograft dysfunction‐free survival

• Published in: Clinical transplantation 2022-06, Vol.36 (6), p.e14639-n/a
• Main Authors: Greenland, Nancy Y., Deiter, Fred, Calabrese, Daniel R., Hays, Steven R., Kukreja, Jasleen, Leard, Lorriana E., Kolaitis, Nicholas A., Golden, Jeffrey A., Singer, Jonathan P., Greenland, John R.
• Format: Article
• Language: English
• Subjects: Allografts; Bronchoalveolar Lavage; bronchoalveolar lavage (BAL); Bronchoalveolar Lavage Fluid; Graft Rejection - diagnosis; Graft Rejection - etiology; Graft vs Host Disease - etiology; Humans; Inflammation - etiology; Lung; lung disease; Lung Transplantation - adverse effects; lung transplantation: living donor; Retrospective Studies
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1111/ctr.14639

Background Lung transplant recipients undergo bronchoalveolar lavage (BAL) to detect antecedents of chronic lung allograft dysfunction (CLAD), but routine assessment of BAL cytology is controversial. We hypothesized that inflammation on BAL cytology would predict CLAD‐free survival. Methods In a single‐center retrospective cohort, associations between cytology results and clinical characteristics were compared using generalized‐estimating equation‐adjusted regression. The association between BAL inflammation and CLAD or death risk was assessed using time‐dependent Cox models. Results  In 3365 cytology reports from 451 subjects, inflammation was the most common finding (6.2%, 210 cases), followed by fungal forms (5.3%, 178 cases, including 24 cases of suspected Aspergillus). Inflammation on BAL cytology was more common in procedures for symptoms (8.5%) versus surveillance (3.2%, p