PKC regulation of ion channels: The involvement of PIP2

Ion channels are integral membrane proteins whose gating has been increasingly shown to depend on the presence of the low-abundance membrane phospholipid, phosphatidylinositol (4,5) bisphosphate. The expression and function of ion channels is tightly regulated via protein phosphorylation by specific...

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Bibliographic Details
Published in:The Journal of biological chemistry 2022-06, Vol.298 (6), p.102035-102035, Article 102035
Main Authors: Gada, Kirin D., Logothetis, Diomedes E.
Format: Article
Language:English
Subjects:
inwardly rectifying potassium channels
ion channel, phosphorylation
JBC Reviews
phosphatidylinositol (4,5) bisphosphate
PKC
transient receptor potential channels
voltage-gated potassium channel
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Summary:Ion channels are integral membrane proteins whose gating has been increasingly shown to depend on the presence of the low-abundance membrane phospholipid, phosphatidylinositol (4,5) bisphosphate. The expression and function of ion channels is tightly regulated via protein phosphorylation by specific kinases, including various PKC isoforms. Several channels have further been shown to be regulated by PKC through altered surface expression, probability of channel opening, shifts in voltage dependence of their activation, or changes in inactivation or desensitization. In this review, we survey the impact of phosphorylation of various ion channels by PKC isoforms and examine the dependence of phosphorylated ion channels on phosphatidylinositol (4,5) bisphosphate as a mechanistic endpoint to control channel gating.
ISSN:0021-9258
1083-351X
DOI:10.1016/j.jbc.2022.102035