Molecular Virology of SARS-CoV-2 and Related Coronaviruses

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The global COVID-19 pandemic continues to threaten the lives of hundreds of millions of people, with a severe negative impact on the global economy. Although several COVID-19 vaccines are c...

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Bibliographic Details
Published in:Microbiology and molecular biology reviews 2022-06, Vol.86 (2), p.e0002621-e0002621
Main Authors: Kung, Yu-An, Lee, Kuo-Ming, Chiang, Huan-Jung, Huang, Sheng-Yu, Wu, Chung-Jung, Shih, Shin-Ru
Format: Article
Language:English
Subjects:
Antiviral agents
Coronaviruses
COVID-19 vaccines
CRISPR
Genomes
Global economy
Impact analysis
Molecular modelling
Pandemics
Public health
Replication
Review
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Vaccines
Viral diseases
Virology
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Summary:Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The global COVID-19 pandemic continues to threaten the lives of hundreds of millions of people, with a severe negative impact on the global economy. Although several COVID-19 vaccines are currently being administered, none of them is 100% effective. Moreover, SARS-CoV-2 variants remain an important worldwide public health issue. Hence, the accelerated development of efficacious antiviral agents is urgently needed. Coronavirus depends on various host cell factors for replication. An ongoing research objective is the identification of host factors that could be exploited as targets for drugs and compounds effective against SARS-CoV-2. In the present review, we discuss the molecular mechanisms of SARS-CoV-2 and related coronaviruses, focusing on the host factors or pathways involved in SARS-CoV-2 replication that have been identified by genome-wide CRISPR screening.
ISSN:1092-2172
1098-5557
DOI:10.1128/mmbr.00026-21