Therapeutic Benefits of Pomegranate Flower Extract: A Novel Effect That Reduces Oxidative Stress and Significantly Improves Diastolic Relaxation in Hyperglycemic In Vitro in Rats

The pomegranate flower is an ancient herb in traditional Chinese medicine with multiple properties. Recent studies have shown that pomegranate flower extract is beneficial, especially for hyperglycemia. In this experiment, we investigated the diastolic effect of pomegranate flower polyphenol (PFP) e...

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Published in:Evidence-based complementary and alternative medicine 2022-06, Vol.2022, p.1-9
Main Authors: Wei, Yuanyuan, Khalaf, Ahmad Taha, Ye, Peng, Fan, Wei, Su, Junyi, Chen, Wanlu, Hu, Hao, Menhas, Rashid, Wang, Lifeng, Oglah, Zahraa
Format: Article
Language:English
Subjects:
Antioxidants
Aorta
Atropine
Blood vessels
Calcium (extracellular)
Calcium (intracellular)
Calcium buffering
Calcium chloride
Calcium influx
Contractility
Coronary vessels
Diabetes
Diabetes mellitus
Endothelium
Ethanol
Glibenclamide
Herbal medicine
Hyperglycemia
Laboratory animals
NG-Nitroarginine methyl ester
Nitric oxide
Oxidative stress
Polyphenols
Potassium
Potassium channels
Potassium chloride
Reagents
Smooth muscle
Supplements
Tetraethylammonium
Thorax
Traditional Chinese medicine
Vasoconstriction
Vasodilation
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Summary:The pomegranate flower is an ancient herb in traditional Chinese medicine with multiple properties. Recent studies have shown that pomegranate flower extract is beneficial, especially for hyperglycemia. In this experiment, we investigated the diastolic effect of pomegranate flower polyphenol (PFP) extract on the isolated thoracic aorta of rats in both the absence and presence of high glucose levels. Isotonic contractile forces were recorded from aortic rings (about 3 mm in length) from rats using the BL-420F Biological Function Test System. Tissues were precontracted with 60 mM KCl to obtain maximum tension under 1.0 g load for 1 hour before the balance was achieved, and the fluid was changed every 15 minutes. PFP (700 mg/L–900 mg/L) showed a concentration-dependent relaxant effect on the aortic rings; vasodilation in the endothelium-intact was significantly higher than that in the de-endothelialized segments P
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/4158762