The characterization of Bordetella pertussis strains isolated in the Central-Western region of Brazil suggests the selection of a specific genetic profile during 2012–2014 outbreaks

Pertussis is a worldwide acute respiratory disease caused by the bacterium Bordetella pertussis. Despite high vaccine coverage, the bacterium continues to circulate in populations and is still one of the most common vaccine-preventable diseases. In Brazil, pertussis incidence has presented a signifi...

Full description

Saved in:
Bibliographic Details
Published in:Epidemiology and infection 2017-05, Vol.145 (7), p.1392-1397
Main Authors: ROCHA, E. L., LEITE, D., CAMARGO, C. H., MARTINS, L. M., SILVA, R. S. N., MARTINS, V. P., CAMPOS, T. A.
Format: Article
Language:English
Subjects:
Age groups
Babies
Bordetella pertussis
Bordetella pertussis - genetics
Brazil - epidemiology
Disease
Disease Outbreaks
Electrophoresis, Gel, Pulsed-Field
Epidemics
Epidemiology
Genotype
Humans
Infant
Infant, Newborn
Laboratories
Original Papers
Pertussis
Pregnancy
Prevalence
Serogroup
Serotyping
Statistical analysis
Surveillance
Vaccines
Whooping cough
Whooping Cough - epidemiology
Whooping Cough - microbiology
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pertussis is a worldwide acute respiratory disease caused by the bacterium Bordetella pertussis. Despite high vaccine coverage, the bacterium continues to circulate in populations and is still one of the most common vaccine-preventable diseases. In Brazil, pertussis incidence has presented a significant decrease since 1990 but since 2011 a sudden increase in incidence has been observed. Thus, the aim of this study was to perform a molecular epidemiological characterization of B. pertussis strains isolated in the Central-Western region (specifically in Distrito Federal) of Brazil from August 2012 to August 2014. During this period, 92 B. pertussis strains were isolated from the outbreaks. All strains were characterized by serotyping and XbaI pulsed-field gel electrophoresis profiles. From August to December 2012, the most prevalent serotype observed was 1,3 (13/17). During 2013 the prevalence of serotype 1,3 decreased (13/30) and from January 2014 to August 2014 the most prevalent serotype was 1,2 (33/45). Fourteen PFGE profiles were identified. Of these, BP-XbaI0039 prevalence increased from 3/17 in 2012 to 10/30 in 2013, and 35/45 in 2014. These results evidence the selection of a specific genetic profile during this period, suggesting the occurrence of a bacterial genomic profile with high circulation potential.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268816003332