Synergistic Impacts of Alpinia oxyphylla Seed Extract and Allopurinol against Experimental Hyperuricemia

In traditional medicine, Alpinia oxyphylla Miquel seed has been used to treat gout and hyperuricemia-related symptoms by enhancing kidney functions. Allopurinol is the most commonly used drug to treat hyperuricemia; however, the drug has many adverse effects. Combining allopurinol with another compo...

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Bibliographic Details
Published in:BioMed research international 2022-06, Vol.2022, p.1-9
Main Authors: Sung, Yoon-Young, Kim, Dong-Seon
Format: Article
Language:English
Subjects:
Allopurinol
Alpinia oxyphylla
Care and treatment
Comparative analysis
Creatinine
Dosage and administration
Drug dosages
Ethanol
Gout
Hyperuricemia
Kidneys
Laboratory animals
Medicine, Chinese
Metabolism
Potassium
Proteins
Rheumatism
Synergistic effect
Urea
Uric acid
Urine
Xanthine oxidase
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Summary:In traditional medicine, Alpinia oxyphylla Miquel seed has been used to treat gout and hyperuricemia-related symptoms by enhancing kidney functions. Allopurinol is the most commonly used drug to treat hyperuricemia; however, the drug has many adverse effects. Combining allopurinol with another compound could reduce the need for high doses and result in improved safety. We investigated the possible synergistic effects of Alpinia oxyphylla seed extract (AE) and allopurinol in decreasing urate concentrations in rats with potassium oxonate-induced hyperuricemia. This study evaluated the effects of allopurinol combined with AE on levels of serum urate, blood urea nitrogen (BUN), and creatinine in a hyperuricemic rat model. The effects of allopurinol plus AE on xanthine oxidase (XOD) activity and urate uptake were measured. The concomitant administration of allopurinol and AE normalized serum urate and reduced BUN and creatinine. The attenuation of hyperuricemia-induced impaired kidney function was related to downregulation of renal urate transporter 1 and upregulation of renal organic anion transporter 1, with inhibition of serum and hepatic XOD activities. The antihyperuricemic effects of allopurinol were enhanced when combined with AE. These results suggested that the combined use of allopurinol and AE may have clinical efficacy in treating hyperuricemia.
ISSN:2314-6133
2314-6141
DOI:10.1155/2022/2824535