Human cells and networks of pain: Transforming pain target identification and therapeutic development

Chronic pain is a disabling disease with limited treatment options. While animal models have revealed important aspects of pain neurobiology, therapeutic translation of this knowledge requires our understanding of these cells and networks of pain in humans. We propose a multi-institutional collabora...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2021-05, Vol.109 (9), p.1426-1429
Main Authors: Renthal, William, Chamessian, Alexander, Curatolo, Michele, Davidson, Steve, Burton, Michael, Dib-Hajj, Sulayman, Dougherty, Patrick M, Ebert, Allison D, Gereau, 4th, Robert W, Ghetti, Andre, Gold, Michael S, Hoben, Gwendolyn, Menichella, Daniela Maria, Mercier, Philippe, Ray, Wilson Z, Salvemini, Daniela, Seal, Rebecca P, Waxman, Stephen, Woolf, Clifford J, Stucky, Cheryl L, Price, Theodore J
Format: Article
Language:English
Subjects:
Animal models
Chronic Pain
Collaboration
Consortia
Data analysis
Genomes
Genotype & phenotype
Humans
Infrastructure
Intersectoral Collaboration
Nervous system
Pain
Pathophysiology
Physiology
Severe acute respiratory syndrome coronavirus 2
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Summary:Chronic pain is a disabling disease with limited treatment options. While animal models have revealed important aspects of pain neurobiology, therapeutic translation of this knowledge requires our understanding of these cells and networks of pain in humans. We propose a multi-institutional collaboration to rigorously and ethically address this challenge.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2021.04.005