Climacteric symptoms in postoperative patients among endometrial cancer, cervical cancer, and ovarian cancer: a cross-sectional study

• Published in: Supportive care in cancer 2022-08, Vol.30 (8), p.6785-6793
• Main Authors: Horiba, Yuko, Yoshino, Tetsuhiro, Yokota, Megumi, Iwata, Takashi, Watanabe, Kenji, Mimura, Masaru, Aoki, Daisuke
• Format: Article
• Language: English
• Subjects: Cancer; Cancer patients; Cancer surgery; Care and treatment; Cervical cancer; Clinics; Cross-sectional studies; Endometrial cancer; Gynecological surgery; Health aspects; Hysterectomy; Medicine; Medicine & Public Health; Menopause; Nursing; Nursing Research; Oncology; Oncology, Experimental; Original; Original Article; Ovarian cancer; Pain Medicine; Postoperative period; Rehabilitation Medicine; Surgery; Surgical outcomes; Women
• ISSN: 0941-4355; 1433-7339
• DOI: 10.1007/s00520-022-07117-z

Purpose To date, no studies have assessed climacteric symptoms after hystero-adnexectomy for endometrial, cervical, or ovarian cancer. Thus, this study aimed to compare climacteric symptoms among patients who underwent surgery for these three cancer types. Methods In this cross-sectional study, we interviewed patients who were registered at a menopausal outpatient clinic between January 1999 and July 2016 after undergoing total hysterectomy, intrapelvic only or intrapelvic plus para-aortic lymph node dissection, and bilateral adnexectomy performed via laparotomy as a cancer treatment. Climacteric symptoms were assessed using a patient-reported questionnaire covering core domains with five symptoms only at the initial consultation. Each symptom was graded from 0 (no symptoms) to 3 (severe symptoms). We evaluated the frequency of symptom severity according to the time elapsed since surgery and the cancer type. Results The numbers of patients with endometrial, ovarian, and cervical cancer were 328, 90, and 107, respectively. Overall, climacteric symptoms were more severe in patients with cervical cancer than in those with endometrial or ovarian cancer; symptom severity decreased with increasing time since surgery. However, symptom severity did not decrease significantly over time in patients with cervical cancer even after > 5 years had elapsed since surgery. Conclusion The climacteric symptoms were less severe in patients with endometrial or ovarian cancer with longer time elapsed since surgery but not in those with cervical cancer. Patients with cervical cancer may require more prompt interventions, including symptomatic treatment and longer follow-up period, than those with endometrial or ovarian cancer.