Correlates of non-persistent endocrine disrupting chemical mixtures among reproductive-aged Black women in Detroit, Michigan

• Published in: Chemosphere (Oxford) 2022-07, Vol.299, p.134447-134447, Article 134447
• Main Authors: Schildroth, Samantha, Wise, Lauren A., Wesselink, Amelia K., Bethea, Traci N., Fruh, Victoria, Taylor, Kyla W., Calafat, Antonia M., Baird, Donna D., Claus Henn, Birgit
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers; Black women; Chemical mixtures; Endocrine disruptors; Endocrine Disruptors - analysis; Environmental Pollutants - analysis; Female; Humans; Michigan; Parabens; Phenols; Phenols - analysis; Phthalates; Phthalic Acids; Prospective Studies
• ISSN: 0045-6535; 1879-1298
• DOI: 10.1016/j.chemosphere.2022.134447

Some studies indicate that Black women have higher exposure to multiple non-persistent endocrine disrupting chemicals (EDCs) than white women, but little is known about correlates of exposure to EDC mixtures. Using baseline data from a prospective cohort study of reproductive-aged Black women (N = 751), we characterized profiles of EDC mixtures and identified correlates of exposure. At baseline, we quantified biomarkers of 16 phthalates, 7 phenols, 4 parabens, and triclocarban in urine and collected covariate data through self-administered questionnaires and interviews. We used principal component (PC) analysis and k-means clustering to describe EDC mixture profiles. Associations between correlates and PCs were estimated as the mean difference (β) in PC scores, while associations between correlates and cluster membership were estimated as the odds ratio (OR) of cluster membership. Personal care product use was consistently associated with profiles of higher biomarker concentrations of non-persistent EDCs. Use of nail polish, menstrual and vaginal products (e.g., vaginal powder, vaginal deodorant), and sunscreen was associated with a mixture of phthalate and some phenol biomarkers using both methods. Current vaginal ring use, a form of hormonal contraception placed inside the vagina, was strongly associated with higher concentrations of high molecular weight phthalate biomarkers (k-means clustering: OR = 2.42, 95% CI = 1.28, 4.59; PCA: β = −0.32, 95% CI = −0.71, 0.07). Several dietary, reproductive, and demographic correlates were also associated with mixtures of EDC biomarkers. These findings suggest that personal care product use, diet, and contraceptive use may be sources of exposure to multiple non-persistent EDCs among reproductive-aged Black women. Targeted interventions to reduce exposure to multiple EDCs among Black women are warranted. [Display omitted] •Black women are exposed to a mixture of endocrine disrupting chemicals (EDCs) from consumer products.•Nail polish, sunscreen, and vaginal product use was associated with a mixture of phthalates, phenols, and parabens.•Targeted strategies to reduce use of certain products may help to reduce exposure to multiple EDCs among Black women.