Drug-Induced Gum Overgrowth With Low-Dose Amlodipine: A Case Report

Drug-induced gingival overgrowth is an adverse effect of certain drugs, including amlodipine, in genetically susceptible individuals. Although the exact mechanism of gingival hypertrophy remains unclear, a unifying multifactorial hypothesis has been constructed. Gingival hypertrophy causes difficult...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-05, Vol.14 (5)
Main Authors: Bhandari, Sadikshya, Siwakoti, Shisir, Shrestha, Shreeya, Gautam, Kushal, Bhandari, Samikshya
Format: Article
Language:English
Subjects:
Anticonvulsants
Blood vessels
Case reports
Cholesterol
Collagen
Connective tissue
Cytokines
Disease prevention
Drug dosages
Fibroblasts
High density lipoprotein
Hypertension
Immunosuppressive agents
Inflammation
Internal Medicine
Medicine
Oral hygiene
Oral Medicine
Pathology
Patients
Potassium
Teeth
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Summary:Drug-induced gingival overgrowth is an adverse effect of certain drugs, including amlodipine, in genetically susceptible individuals. Although the exact mechanism of gingival hypertrophy remains unclear, a unifying multifactorial hypothesis has been constructed. Gingival hypertrophy causes difficulty in speech and mastication, poor oral hygiene, and poor aesthetic appearance. Here, we present the case of a 49-year-old woman who developed gum hypertrophy following amlodipine use for two years. Maintenance of oral hygiene and substitution of offending agent is commonly the first step in management.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.25220