Persistent RNA SARS-CoV-2 Detection in a HIV-Infected Patient

The aim of this paper is to present a case of COVID-19 in a newly diagnosed HIV-infected, severely immunodepressed patient with a long persistence of positive RT-PCR for RNA SARS-CoV-2. Indirect data suggests that viable virus persisted for a long time in the absence of an adequate defense of the ho...

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Bibliographic Details
Published in:Healthcare (Basel) 2022-05, Vol.10 (6), p.982
Main Authors: Giubelan, Lucian, Stanciu, Ilona, Ilie, Cristina, Pădureanu, Vlad
Format: Article
Language:English
Subjects:
Coronaviruses
Infectious diseases
Laboratories
Mutation
Severe acute respiratory syndrome coronavirus 2
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Summary:The aim of this paper is to present a case of COVID-19 in a newly diagnosed HIV-infected, severely immunodepressed patient with a long persistence of positive RT-PCR for RNA SARS-CoV-2. Indirect data suggests that viable virus persisted for a long time in the absence of an adequate defense of the host. Improved immunity after starting antiretroviral treatment was not associated with an increased inflammatory reaction as regarding the infection due to the coronavirus and, apparently, was the main factor to control the infection. Remdesivir used to combat the SARS-CoV-2 infection had no immediate effect on the recorded cycle-threshold.
ISSN:2227-9032
2227-9032
DOI:10.3390/healthcare10060982