Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3

Mycobacterium tuberculosis complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest tuberculosis burden. To investigate the population structure and the global diversity of this major lineage, we analyzed a dataset comprising 2682 L3 strains from 38 countries over 5 conti...

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Bibliographic Details
Published in:Genes 2022-05, Vol.13 (6), p.990
Main Authors: Shuaib, Yassir A., Utpatel, Christian, Kohl, Thomas A., Barilar, Ivan, Diricks, Margo, Ashraf, Nadia, Wieler, Lothar H., Kerubo, Glennah, Mesfin, Eyob A., Diallo, Awa Ba, Al-Hajoj, Sahal, Ndung’u, Perpetua, Fitzgibbon, Margaret M., Vaziri, Farzam, Sintchenko, Vitali, Martinez, Elena, Viegas, Sofia O., Zhou, Yang, Azmy, Aya, Al-Amry, Khaled, Godreuil, Sylvain, Varma-Basil, Mandira, Narang, Anshika, Ali, Solomon, Beckert, Patrick, Dreyer, Viola, Kabwe, Mwila, Bates, Matthew, Hoelscher, Michael, Rachow, Andrea, Gori, Andrea, Tekwu, Emmanuel M., Sidze, Larissa K., Jean-Paul, Assam A., Beng, Veronique P., Ntoumi, Francine, Frank, Matthias, Diallo, Aissatou Gaye, Mboup, Souleymane, Tessema, Belay, Beyene, Dereje, Khan, Sadiq N., Diel, Roland, Supply, Philip, Maurer, Florian P., Hoffmann, Harald, Niemann, Stefan, Merker, Matthias
Format: Article
Language:English
Subjects:
Bacteriology
Clinical isolates
Clinical trials
Drug development
Evolution
Genetic diversity
Genetics
Genotype
Genotyping
Life Sciences
Microbial Sensitivity Tests
Microbiology and Parasitology
Minisatellite Repeats
Mycobacterium tuberculosis
Phylogenetics
Phylogeny
Population
Population structure
Populations and Evolution
Strains (organisms)
Tuberculosis
Vaccines
Whole genome sequencing
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Summary:Mycobacterium tuberculosis complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest tuberculosis burden. To investigate the population structure and the global diversity of this major lineage, we analyzed a dataset comprising 2682 L3 strains from 38 countries over 5 continents, by employing 24-loci mycobacterial interspersed repetitive unit-variable number of tandem repeats genotyping (MIRU-VNTR) and drug susceptibility testing. We further combined whole-genome sequencing (WGS) and phylogeographic analysis for 373 strains representing the global L3 genetic diversity. Ancestral state reconstruction confirmed that the origin of L3 strains is located in Southern Asia and further revealed multiple independent introduction events into North-East and East Africa. This study provides a systematic understanding of the global diversity of L3 strains and reports phylogenetic variations that could inform clinical trials which evaluate the effectivity of new drugs/regimens or vaccine candidates.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes13060990