Epidemiological Characteristics and Mortality Risk Factors Comparison in Dialysis and Non-Dialysis CKD Patients with COVID-19-A Single Center Experience

(1) Background: Despite some controversies between studies, chronic kidney disease (CKD) has a negative impact on COVID-19 outcomes, with patients presenting a higher mortality risk than in the general population. Studies have shown an association between COVID-19 severe cases and different inflamma...

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Bibliographic Details
Published in:Journal of personalized medicine 2022-06, Vol.12 (6), p.966
Main Authors: Niculae, Andrei, Peride, Ileana, Nechita, Ana-Maria, Petcu, Lucian Cristian, Tiglis, Mirela, Checherita, Ionel Alexandru
Format: Article
Language:English
Subjects:
Biomarkers
Coronaviruses
COVID-19
Creatinine
Diabetes
Dialysis
Enzymes
Epidemiology
Ferritin
Hemodialysis
Hemoglobin
Hospitals
Hypothesis testing
Independent sample
Infections
Inflammation
Interleukin 6
Kidney diseases
Kinases
Length of stay
Mortality
Patients
Population studies
Precision medicine
Procalcitonin
Proteins
Risk factors
Severe acute respiratory syndrome coronavirus 2
Signal transduction
Statistical analysis
Variables
Ventilation
Ventilators
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Summary:(1) Background: Despite some controversies between studies, chronic kidney disease (CKD) has a negative impact on COVID-19 outcomes, with patients presenting a higher mortality risk than in the general population. Studies have shown an association between COVID-19 severe cases and different inflammatory biomarkers. The aim of this study was to emphasize the epidemiological characteristics of CKD patients diagnosed with COVID-19 and to determine if the risk of mortality, and the severity of this infection might be influenced by different parameters. (2) Methods: Our retrospective study included CKD patients with COVID-19—362 in the non-dialysis group and 132 in the dialysis group. (3) Results: There were significant statistical differences between our groups regarding age (p < 0.001), hemoglobin (p < 0.001), interleukin-6 (p < 0.001), serum albumin (p = 0.016), procalcitonin (p = 0.002), ferritin (p < 0.001), and of course serum creatinine (p < 0.001). Even if the risk of death was higher in the dialysis group (Exp(b) = 1.839), the survival proportions were similar in both groups. (4) Conclusions: High values of hemoglobin, serum creatinine, and LDH at admission, age, length of hospital stay ≤ 10 days, and a pulmonary impairment > 25% are responsible for an adverse outcome in non-dialysis and dialysis patients diagnosed with COVID-19.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12060966