Ameliorating Effect of Malva neglecta Wallr on Obesity and Diabetes in Wistar Rats: A Mechanistic Study

A high caloric food causes deposition of fats that may progress to obesity. Obesity is a risk factor for various metabolic and cardiovascular diseases, including but limited to diabetes mellitus. This study is aimed at determining the ameliorating effect of Malva Neglecta wallr aqueous-methanolic ex...

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Published in:BioMed research international 2022, Vol.2022 (1), p.0-2614599
Main Authors: Akhtar, Muhammad Furqan, Farooq, Umar, Saleem, Ammara, Saleem, Mohammad, Rahman, Md Habibur, Ashraf, Ghulam Md
Format: Article
Language:English
Subjects:
Acids
Alloxan
Amylases
Analysis
Antidiabetics
Antioxidants
Blood glucose
Body mass index
Body weight
Carbohydrates
Cardiovascular diseases
Care and treatment
Cholesterol
Diabetes
Diabetes mellitus
Diabetic neuropathy
Disease control
Flavonoids
High fat diet
High performance liquid chromatography
Identification and classification
Insulin
Insulin resistance
Kidneys
Leptin
Liquid chromatography
Liver
Materia medica, Vegetable
Metabolism
Metabolites
Obesity
Oxidation resistance
Oxidative stress
Pancreas
Phenolic acids
Phenols
Phytochemicals
Plant extracts
Potassium
Properties
Reagents
Risk analysis
Risk factors
Scavenging
Sodium
Urea
Weight control
α-Amylase
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Summary:A high caloric food causes deposition of fats that may progress to obesity. Obesity is a risk factor for various metabolic and cardiovascular diseases, including but limited to diabetes mellitus. This study is aimed at determining the ameliorating effect of Malva Neglecta wallr aqueous-methanolic extract (MNME) on obesity and diabetes in Wistar rats. The MNME was chemically characterized by high-performance liquid chromatography (HPLC). The plant extract was evaluated by in vitro α-amylase inhibition and DPPH scavenging activities. Obesity was induced by administering high sugar and fat diet (HSFD) to rats for six weeks, followed by intraperitoneal injection of alloxan monohydrate (150 mg/kg) to induce diabetes. Oral treatments with MNME 250, 500, and 750 mg/kg/day were given to diabetic obese rats for 14 days. The HPLC analysis showed the presence of phenolic acids and flavonoids. The plant extract showed significant antioxidant (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2022/2614599