Effect of different voxel sizes on the accuracy of CBCT measurements of trabecular bone microstructure: A comparative micro-CT study

PurposeThe aim of this study was to assess the accuracy of cone-beam computed tomographic (CBCT) images obtained using different voxel sizes in measuring trabecular bone microstructure in comparison to micro-CT. Materials and MethodsTwelve human skull bones containing posterior-mandibular alveolar b...

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Published in:Imaging science in dentistry 2022-06, Vol.52 (2), p.171-179
Main Authors: Tayman, Mahmure Ayşe, Kamburoğlu, Kıvanç, Ocak, Mert, Özen, Doğukan
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Kamburoğlu, Kıvanç
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description PurposeThe aim of this study was to assess the accuracy of cone-beam computed tomographic (CBCT) images obtained using different voxel sizes in measuring trabecular bone microstructure in comparison to micro-CT. Materials and MethodsTwelve human skull bones containing posterior-mandibular alveolar bone regions were analyzed. CBCT images were obtained at voxel sizes of 0.075 mm (high: HI) and 0.2 mm (standard: Std), while micro-CT imaging used voxel sizes of 0.06 mm (HI) and 0.12 mm (Std). Analyses were performed using CTAn software with the standardized automatic global threshold method. Intraclass correlation coefficients were used to evaluate the consistency and agreement of paired measurements for bone volume (BV), percent bone volume (BV/TV), bone surface (BS), trabecular thickness (TbTh), trabecular separation (TbSp), trabecular number (TbN), trabecular pattern factor (TbPf), and structure model index (SMI). ResultsWhen compared to micro-CT, CBCT images had higher BV, BV/TV, and TbTh values, while micro-CT images had lower BS, TbSp, TbN, TbPf, and SMI values (P
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Materials and MethodsTwelve human skull bones containing posterior-mandibular alveolar bone regions were analyzed. CBCT images were obtained at voxel sizes of 0.075 mm (high: HI) and 0.2 mm (standard: Std), while micro-CT imaging used voxel sizes of 0.06 mm (HI) and 0.12 mm (Std). Analyses were performed using CTAn software with the standardized automatic global threshold method. Intraclass correlation coefficients were used to evaluate the consistency and agreement of paired measurements for bone volume (BV), percent bone volume (BV/TV), bone surface (BS), trabecular thickness (TbTh), trabecular separation (TbSp), trabecular number (TbN), trabecular pattern factor (TbPf), and structure model index (SMI). ResultsWhen compared to micro-CT, CBCT images had higher BV, BV/TV, and TbTh values, while micro-CT images had lower BS, TbSp, TbN, TbPf, and SMI values (P&lt;0.05). The BV, BV/BT, TbTh, and TbSp variables were higher with Std voxels, whereas the BS, TbPf, and SMI variables were higher with HI voxels for both imaging methods. For each imaging modality and voxel size evaluated, BV, BS, and TbTh were significantly different (P&lt;0.05). TbN, TbPf, and SMI showed statistically significant differences between imaging methods (P&lt;0.05). The consistency and absolute agreement between micro-CT and CBCT were excellent for all variables. ConclusionThis study demonstrated the potential of high-resolution CBCT imaging for quantitative bone morphometry assessment.</description><identifier>ISSN: 2233-7822</identifier><identifier>EISSN: 2233-7830</identifier><identifier>DOI: 10.5624/isd.20220025</identifier><identifier>PMID: 35799972</identifier><language>eng</language><publisher>Korean Academy of Oral and Maxillofacial Radiology</publisher><subject>Original</subject><ispartof>Imaging science in dentistry, 2022-06, Vol.52 (2), p.171-179</ispartof><rights>Copyright © 2022 by Korean Academy of Oral and Maxillofacial Radiology 2022 Korean Academy of Oral and Maxillofacial Radiology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c291t-34f04a0a371a0f3709964caac8d112d61db2007696728f47ca0fac8bee7aca4b3</citedby><cites>FETCH-LOGICAL-c291t-34f04a0a371a0f3709964caac8d112d61db2007696728f47ca0fac8bee7aca4b3</cites><orcidid>0000-0001-6832-6208 ; 0000-0002-4134-5756 ; 0000-0001-8924-6725 ; 0000-0003-1943-2690</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226237/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226237/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Tayman, Mahmure Ayşe</creatorcontrib><creatorcontrib>Kamburoğlu, Kıvanç</creatorcontrib><creatorcontrib>Ocak, Mert</creatorcontrib><creatorcontrib>Özen, Doğukan</creatorcontrib><title>Effect of different voxel sizes on the accuracy of CBCT measurements of trabecular bone microstructure: A comparative micro-CT study</title><title>Imaging science in dentistry</title><description>PurposeThe aim of this study was to assess the accuracy of cone-beam computed tomographic (CBCT) images obtained using different voxel sizes in measuring trabecular bone microstructure in comparison to micro-CT. Materials and MethodsTwelve human skull bones containing posterior-mandibular alveolar bone regions were analyzed. CBCT images were obtained at voxel sizes of 0.075 mm (high: HI) and 0.2 mm (standard: Std), while micro-CT imaging used voxel sizes of 0.06 mm (HI) and 0.12 mm (Std). Analyses were performed using CTAn software with the standardized automatic global threshold method. Intraclass correlation coefficients were used to evaluate the consistency and agreement of paired measurements for bone volume (BV), percent bone volume (BV/TV), bone surface (BS), trabecular thickness (TbTh), trabecular separation (TbSp), trabecular number (TbN), trabecular pattern factor (TbPf), and structure model index (SMI). ResultsWhen compared to micro-CT, CBCT images had higher BV, BV/TV, and TbTh values, while micro-CT images had lower BS, TbSp, TbN, TbPf, and SMI values (P&lt;0.05). The BV, BV/BT, TbTh, and TbSp variables were higher with Std voxels, whereas the BS, TbPf, and SMI variables were higher with HI voxels for both imaging methods. For each imaging modality and voxel size evaluated, BV, BS, and TbTh were significantly different (P&lt;0.05). TbN, TbPf, and SMI showed statistically significant differences between imaging methods (P&lt;0.05). The consistency and absolute agreement between micro-CT and CBCT were excellent for all variables. ConclusionThis study demonstrated the potential of high-resolution CBCT imaging for quantitative bone morphometry assessment.</description><subject>Original</subject><issn>2233-7822</issn><issn>2233-7830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVkU9r3DAQxUVpaEKSWz6Ajj3UiTzyWlYPhXTJP1jIZXMWY3ncqNjWVpKXbM_94NGSbSBzmUHvxxsxj7GLUlwuaqiuXOwuQQAIAYtP7ARAykI1Unx-nwGO2XmMv0WuBTSqLr-wY7lQWmsFJ-zfTd-TTdz3vHN5DDQlvvUvNPDo_lLkfuLpmThaOwe0uz24_Llc85EwzoHGzMf9YwrYkp0HDLz1E_HR2eBjCrNNGfvOr7n14wYDJrc9qEW2iWnudmfsqMch0vmhn7Kn25v18r5YPd49LK9XhQVdpkJWvahQoFQlil4qoXVdWUTbdGUJXV12bT6EqnWtoOkrZTOVxZZIocWqlafsx5vvZm5H6mz-e8DBbIIbMeyMR2c-KpN7Nr_81miAGqTKBl8PBsH_mSkmM7poaRhwIj9HA3WjFMhG6Ix-e0P3Z4iB-vc1pTD77EzOzvzPTr4CF6OOCA</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Tayman, Mahmure Ayşe</creator><creator>Kamburoğlu, Kıvanç</creator><creator>Ocak, Mert</creator><creator>Özen, Doğukan</creator><general>Korean Academy of Oral and Maxillofacial Radiology</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6832-6208</orcidid><orcidid>https://orcid.org/0000-0002-4134-5756</orcidid><orcidid>https://orcid.org/0000-0001-8924-6725</orcidid><orcidid>https://orcid.org/0000-0003-1943-2690</orcidid></search><sort><creationdate>20220601</creationdate><title>Effect of different voxel sizes on the accuracy of CBCT measurements of trabecular bone microstructure: A comparative micro-CT study</title><author>Tayman, Mahmure Ayşe ; Kamburoğlu, Kıvanç ; Ocak, Mert ; Özen, Doğukan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-34f04a0a371a0f3709964caac8d112d61db2007696728f47ca0fac8bee7aca4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Tayman, Mahmure Ayşe</creatorcontrib><creatorcontrib>Kamburoğlu, Kıvanç</creatorcontrib><creatorcontrib>Ocak, Mert</creatorcontrib><creatorcontrib>Özen, Doğukan</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Imaging science in dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tayman, Mahmure Ayşe</au><au>Kamburoğlu, Kıvanç</au><au>Ocak, Mert</au><au>Özen, Doğukan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of different voxel sizes on the accuracy of CBCT measurements of trabecular bone microstructure: A comparative micro-CT study</atitle><jtitle>Imaging science in dentistry</jtitle><date>2022-06-01</date><risdate>2022</risdate><volume>52</volume><issue>2</issue><spage>171</spage><epage>179</epage><pages>171-179</pages><issn>2233-7822</issn><eissn>2233-7830</eissn><abstract>PurposeThe aim of this study was to assess the accuracy of cone-beam computed tomographic (CBCT) images obtained using different voxel sizes in measuring trabecular bone microstructure in comparison to micro-CT. Materials and MethodsTwelve human skull bones containing posterior-mandibular alveolar bone regions were analyzed. CBCT images were obtained at voxel sizes of 0.075 mm (high: HI) and 0.2 mm (standard: Std), while micro-CT imaging used voxel sizes of 0.06 mm (HI) and 0.12 mm (Std). Analyses were performed using CTAn software with the standardized automatic global threshold method. Intraclass correlation coefficients were used to evaluate the consistency and agreement of paired measurements for bone volume (BV), percent bone volume (BV/TV), bone surface (BS), trabecular thickness (TbTh), trabecular separation (TbSp), trabecular number (TbN), trabecular pattern factor (TbPf), and structure model index (SMI). ResultsWhen compared to micro-CT, CBCT images had higher BV, BV/TV, and TbTh values, while micro-CT images had lower BS, TbSp, TbN, TbPf, and SMI values (P&lt;0.05). The BV, BV/BT, TbTh, and TbSp variables were higher with Std voxels, whereas the BS, TbPf, and SMI variables were higher with HI voxels for both imaging methods. For each imaging modality and voxel size evaluated, BV, BS, and TbTh were significantly different (P&lt;0.05). TbN, TbPf, and SMI showed statistically significant differences between imaging methods (P&lt;0.05). The consistency and absolute agreement between micro-CT and CBCT were excellent for all variables. ConclusionThis study demonstrated the potential of high-resolution CBCT imaging for quantitative bone morphometry assessment.</abstract><pub>Korean Academy of Oral and Maxillofacial Radiology</pub><pmid>35799972</pmid><doi>10.5624/isd.20220025</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6832-6208</orcidid><orcidid>https://orcid.org/0000-0002-4134-5756</orcidid><orcidid>https://orcid.org/0000-0001-8924-6725</orcidid><orcidid>https://orcid.org/0000-0003-1943-2690</orcidid><oa>free_for_read</oa></addata></record>
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title Effect of different voxel sizes on the accuracy of CBCT measurements of trabecular bone microstructure: A comparative micro-CT study
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