Role of Phytoestrogen-Rich Bioactive Substances ( Linum usitatissimum L., Glycine max L., Trifolium pratense L.) in Cardiovascular Disease Prevention in Postmenopausal Women: A Systematic Review and Meta-Analysis

• Published in: Nutrients 2022-06, Vol.14 (12), p.2467
• Main Authors: Błaszczuk, Agata, Barańska, Agnieszka, Kanadys, Wiesław, Malm, Maria, Jach, Monika Elżbieta, Religioni, Urszula, Wróbel, Rafał, Herda, Jolanta, Polz-Dacewicz, Małgorzata
• Format: Article
• Language: English
• Subjects: Biological activity; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - prevention & control; Chemical properties; Cholesterol; Cholesterol, LDL; Confidence intervals; Female; Flax; Flaxseed; Food and nutrition; Glycine max; Health aspects; High density lipoprotein; Humans; Isoflavones; Kinases; Lipids; Low density lipoprotein; Meta-analysis; Phytoestrogens; Phytoestrogens - pharmacology; Post-menopause; Postmenopausal women; Postmenopause; Prevention; Red clover; Risk factors; Soybean; Soybeans; Statistical analysis; Systematic review; Trifolium; Trifolium pratense
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu14122467

The aim of this report was to determine the impact of flaxseed, soy and red clover, and their bioactive substances on the lipid profile in postmenopausal women in cardiovascular diseases prevention. We used the following databases: MEDLINE (PubMed), EMBASE and the Cochrane Library. Meta-analysis indicates that the intake of flaxseed by postmenopausal women is associated with a statistically significant reduction in total cholesterol (TC) levels (weighted-mean difference (WMD) = -0.26; 95% confidence interval (95% CI): -0.38 to -0.13; = 0.0001), low-density lipoprotein cholesterol (LDL-C) levels (WMD = -0.19; 95% CI: -0.30 to -0.08; = 0.0006), and high-density lipoprotein cholesterol (HDL-C) levels (WMD = -0.06; 95% CI: -0.11 to -0.01; = 0.0150). The effect of soy protein on the lipid profile showed a significant decrease in TC levels: WMD = -0.15; 95% CI: -0.25-0.05; = 0.0048, LDL-C levels: WMD = -0.15; 95% CI: -0.25-0.05; = 0.0067, as well as a significant increase in HDL-C levels: WMD = 0.05; 95% CI: 0.02-0.08; = 0.0034. Changes in the lipid profile showed a significant reduction in TC levels after the use of red clover (WMD = -0.11; 95% CI: -0.18--0.04; = 0.0017) and a significant increase in HDL-C levels (WMD = 0.04; 95% CI: 0.01 to 0.07; = 0.0165). This meta-analysis provides evidence that consuming flaxseed, soy and red clover can have a beneficial effect on lipids in postmenopausal women and suggest a favorable effect in preventing cardiovascular diseases.