Sulfur regulation of the sulfate transporter genes sutA and sutB in Penicillium chrysogenum

Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yieldi...

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Bibliographic Details
Published in:Applied and environmental microbiology 2000-10, Vol.66 (10), p.4536-4538
Main Authors: VAN DE KAMP, Mart, SCHUURS, Theo A, VOS, Arnold, VAN DER LENDE, Ted R, KONINGS, Wil N, DRIESSEN, Arnold J. M
Format: Article
Language:English
Subjects:
Anion Transport Proteins
Bacteria
Biological and medical sciences
Biology of microorganisms of confirmed or potential industrial interest
Biotechnology
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cation Transport Proteins
Fundamental and applied biological sciences. Psychology
Fungal Proteins
Genes
Genetics
Microbiology
Mission oriented research
Mycology
Penicillin
Penicillium chrysogenum
Penicillium chrysogenum - genetics
Penicillium chrysogenum - metabolism
Ribonucleic acid
RNA
sulfate transporters
Sulfates - metabolism
Sulfur
sutA gene
sutB gene
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Summary:Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.
ISSN:0099-2240
1098-5336
DOI:10.1128/AEM.66.10.4536-4538.2000