Neural correlates of blood flow measured by ultrasound

Functional ultrasound imaging (fUSI) is an appealing method for measuring blood flow and thus infer brain activity, but it relies on the physiology of neurovascular coupling and requires extensive signal processing. To establish to what degree fUSI trial-by-trial signals reflect neural activity, we...

Full description

Saved in:
Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2022-05, Vol.110 (10), p.1631-1640.e4
Main Authors: Nunez-Elizalde, Anwar O., Krumin, Michael, Reddy, Charu Bai, Montaldo, Gabriel, Urban, Alan, Harris, Kenneth D., Carandini, Matteo
Format: Article
Language:English
Subjects:
Animals
Cerebral Cortex
electrophysiology
hemodynamic coupling
Hemodynamics - physiology
Mice
Neurons - physiology
Neurovascular Coupling
Ultrasonography - methods
ultrasound measurements
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Functional ultrasound imaging (fUSI) is an appealing method for measuring blood flow and thus infer brain activity, but it relies on the physiology of neurovascular coupling and requires extensive signal processing. To establish to what degree fUSI trial-by-trial signals reflect neural activity, we performed simultaneous fUSI and neural recordings with Neuropixels probes in awake mice. fUSI signals strongly correlated with the slow (
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2022.02.012