Clinical Characteristics and Treatment Response in Microscopic Colitis Based on Age at Diagnosis: A Multicenter Retrospective Study

• Published in: Digestive diseases and sciences 2022-07, Vol.67 (7), p.3108-3114
• Main Authors: Kamboj, Amrit K., McGoldrick, Jessica, Voth, Eli, Penrice, Daniel, Tome, June, Gujral, Amandeep, Miller, Kaia, Burke, Kristin E., Pardi, Darrell S., Khalili, Hamed
• Format: Article
• Language: English
• Subjects: Age; Biochemistry; Colitis; Drug therapy; Gastroenterology; Hepatology; Inflammatory bowel disease; Medical diagnosis; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Oncology; Original; Original Article; Remission (Medicine); Transplant Surgery
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-021-07162-4

Background Microscopic colitis (MC) primarily affects older adults; thus, data in younger patients are scarce. Aims To compare clinical characteristics and treatment response by age at diagnosis. Methods This retrospective cohort study was performed at Mayo Clinic and Massachusetts General Hospital. Patients were chosen consecutively using established databases. Patients were ‘younger’ if age at diagnosis was ≤ 50 years and ‘older’ if age > 50 years. Treatment outcomes were captured for induction (12 ± 4 weeks), based on the total number of daily stools, and defined as remission (complete resolution), response (≥ 50% improvement), non-response ( 0.05). Younger patients were more likely to have celiac disease (17.3% vs. 5.8%, P  = 0.01), while older patients had higher BMI (mean 25.0 vs. 23.8 kg/m 2 , P  = 0.04) were more likely smokers (53.9% vs. 34.6%, P  = 0.01) and use NSAIDs (48.6% vs. 15.4%, P