Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens

In the era of antimicrobial resistance, the identification of new compounds with strong antimicrobial activity and the development of alternative therapies to fight drug-resistant bacteria are urgently needed. Here, we have used resveratrol, a safe and well-known plant-derived stilbene with poor ant...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2022-06, Vol.85 (6), p.1459-1473
Main Authors: Cebrián, Rubén, Li, Qian, Peñalver, Pablo, Belmonte-Reche, Efres, Andrés-Bilbao, María, Lucas, Ricardo, de Paz, María Violante, Kuipers, Oscar P., Morales, Juan Carlos
Format: Article
Language:English
Subjects:
aminoglycosides
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
antibacterial properties
antibiotic resistance
antimicrobial peptides
cell lines
cross resistance
Gram-Negative Bacteria
Gram-Positive Bacteria
hemolysis
mechanism of action
membrane permeability
Microbial Sensitivity Tests
Resveratrol
synergism
toxicity
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Summary:In the era of antimicrobial resistance, the identification of new compounds with strong antimicrobial activity and the development of alternative therapies to fight drug-resistant bacteria are urgently needed. Here, we have used resveratrol, a safe and well-known plant-derived stilbene with poor antimicrobial properties, as a scaffold to design several new families of antimicrobials by adding different chemical entities at specific positions. We have characterized the mode of action of the most active compounds prepared and have examined their synergistic antibacterial activity in combination with traditional antibiotics. Some alkyl- and silyl-resveratrol derivatives show bactericidal activity against Gram-positive bacteria in the same low micromolar range of traditional antibiotics, with an original mechanism of action that combines membrane permeability activity with ionophore-related activities. No cross-resistance or antagonistic effect was observed with traditional antibiotics. Synergism was observed for some specific general-use antibiotics, such as aminoglycosides and cationic antimicrobial peptide antibiotics. No hemolytic activity was observed at the active concentrations or above, although some low toxicity against an MRC-5 cell line was noted.
ISSN:0163-3864
1520-6025
1520-6025
DOI:10.1021/acs.jnatprod.1c01107