Extracellular vesicles in Alzheimer's disease: from pathology to therapeutic approaches

Alzheimer's disease is a progressive and fatal neurodegenerative disorder that starts many years before the onset of cognitive symptoms. Identifying novel biomarkers for Alzheimer's disease has the potential for patient risk stratification, early diagnosis, and disease monitoring in respon...

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Bibliographic Details
Published in:Neural regeneration research 2023-01, Vol.18 (1), p.18-22
Main Authors: Garcia-Contreras, Marta, Thakor, Avnesh
Format: Article
Language:English
Subjects:
Alzheimer's disease
Extracellular vesicles
Review
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Summary:Alzheimer's disease is a progressive and fatal neurodegenerative disorder that starts many years before the onset of cognitive symptoms. Identifying novel biomarkers for Alzheimer's disease has the potential for patient risk stratification, early diagnosis, and disease monitoring in response to therapy. A novel class of biomarkers is extracellular vesicles given their sensitivity and specificity to specific diseases. In addition, extracellular vesicles can be used as novel biological therapeutics given their ability to efficiently and functionally deliver therapeutic cargo. This is critical given the huge unmet need for novel treatment strategies for Alzheimer's disease. This review summarizes and discusses the most recent findings in this field.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.343882