Arterial function, biomarkers, carcinoid syndrome and carcinoid heart disease in patients with small intestinal neuroendocrine tumours

Purpose Carcinoid heart disease (CHD) is a life-threatening complication of carcinoid syndrome (CS) characterised by tricuspid regurgitation (TR). However, there is an unmet need for earlier diagnosis of CHD. We cross-sectionally assessed the prevalence and potential predictive or diagnostic markers...

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Published in:Endocrine 2022-06, Vol.77 (1), p.177-187
Main Authors: Kostiainen, Iiro, Karppinen, Noora, Simonen, Piia, Rosengård-Bärlund, Milla, Lindén, Riikka, Tarkkanen, Maija, Gordin, Daniel, Rapola, Janne, Schalin-Jäntti, Camilla, Matikainen, Niina
Format: Article
Language:English
Subjects:
Arteriosclerosis
Atherosclerosis
Biochemical characteristics
Cardiovascular disease
Coronary artery disease
Diabetes
Diarrhea
Echocardiography
Endocrinology
Heart diseases
Humanities and Social Sciences
Internal Medicine
Intestine
Liver
Medicine
Medicine & Public Health
multidisciplinary
Neuroendocrine tumors
Original
Original Article
Regurgitation
Science
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Summary:Purpose Carcinoid heart disease (CHD) is a life-threatening complication of carcinoid syndrome (CS) characterised by tricuspid regurgitation (TR). However, there is an unmet need for earlier diagnosis of CHD. We cross-sectionally assessed the prevalence and potential predictive or diagnostic markers for CS and CHD in a contemporary cohort of patients with small intestinal neuroendocrine tumours (SI-NETs). Methods Biochemical characteristics, hepatic tumour load, measures of arterial and endothelial function, atherosclerosis, and transthoracic echocardiography were analysed in a prospective cross-sectional setting. Results Among the 65 patients studied, 29 (45%) had CS (CS+ ), and 3 (5%) CHD. CS+ was characterised by significantly higher hepatic tumour load, S-5-HIAA and fP-CgA, higher frequency of diarrhoea and flushing, and more frequent PRRT compared to CS− (for all, P  
ISSN:1559-0100
1355-008X
1559-0100
DOI:10.1007/s12020-022-03065-0