Associations of the Cardiometabolic Index with the Risk of Cardiovascular Disease in Patients with Hypertension and Obstructive Sleep Apnea: Results of a Longitudinal Cohort Study

Purpose. We aimed to explore the relationship between the cardiometabolic index (CMI) and cardiovascular disease (CVD) and its subtypes (coronary artery disease and stroke) in patients with hypertension and obstructive sleep apnea (OSA). Methods. We conducted a retrospective cohort study enrolling 2...

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Published in:Oxidative medicine and cellular longevity 2022-06, Vol.2022, p.1-15
Main Authors: Cai, Xintian, Hu, Junli, Wen, Wen, Wang, Jingyu, Wang, Mengru, Liu, Shasha, Zhu, Qing, Hong, Jing, Dang, Yujie, Yao, Xiaoguang, Sun, Le, Zhang, Delian, Luo, Qin, Li, Nanfang
Format: Article
Language:English
Subjects:
Angina pectoris
Angioplasty
Body fat
Cardiovascular disease
Cholesterol
Cohort analysis
Diabetes
Epidemiology
Glucose
High density lipoprotein
Hospitals
Hypertension
Laboratories
Magnetic resonance imaging
Medical records
Metabolism
Regression analysis
Sleep apnea
Stroke
Tomography
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Summary:Purpose. We aimed to explore the relationship between the cardiometabolic index (CMI) and cardiovascular disease (CVD) and its subtypes (coronary artery disease and stroke) in patients with hypertension and obstructive sleep apnea (OSA). Methods. We conducted a retrospective cohort study enrolling 2067 participants from the Urumqi Research on Sleep Apnea and Hypertension study. The CMI was calculated as triglyceride to high‐density lipoprotein cholesterol ratio×waist‐to‐height ratio. Participants were divided into three groups (T1, T2, and T3) according to the tertile of CMI. The Kaplan-Meier method helped to calculate the cumulative incidence of CVD in different groups. We assessed the association of CMI with the risk of CVD and CVD subtypes by estimating hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox models. Results. During a median follow-up of 6.83 years (interquartile range: 5.92-8.00 years), 326 incident CVD were identified, including 121 incident stroke and 205 incident coronary heart disease (CHD). Overall, after adjusting for confounding variables, CMI was positively associated with the risk of new-onset CVD (per SD increment, adjusted HR: 1.31; 95% CI: 1.20, 1.43), new-onset CHD (per SD increment, adjusted HR: 1.33; 95% CI: 1.20, 1.48), and new-onset stroke (per SD increment, adjusted HR: 1.27; 95% CI: 1.10, 1.47). Similar results were obtained in various subgroup and sensitivity analyses. Adding CMI to the baseline risk model for CVD improved the C-index (P
ISSN:1942-0900
1942-0994
DOI:10.1155/2022/4914791