Quantitative assessment of intratumoral 2-[18F]FDG metabolic spatial distribution in hypermetabolic pulmonary lesions in PET/CT

BackgroundThe purpose of this study was to evaluate the value of quantitative assessment of intratumoral 2-deoxy-2-[18F]fluoro-D-glucose (2-[18F]FDG) metabolic spatial distribution (Q-FMSD) in differentiating pulmonary lesions with high 2-[18F]FDG uptake. MethodsIn this retrospective study, a total...

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Published in:Quantitative imaging in medicine and surgery 2022-07, Vol.12 (7), p.3821-3832
Main Authors: Wang, Ling, Jiang, Jia, Xue, Beihui, Lin, Jie, Ji, Xiaowei, Zheng, Xiangwu, Tang, Kun
Format: Article
Language:English
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Summary:BackgroundThe purpose of this study was to evaluate the value of quantitative assessment of intratumoral 2-deoxy-2-[18F]fluoro-D-glucose (2-[18F]FDG) metabolic spatial distribution (Q-FMSD) in differentiating pulmonary lesions with high 2-[18F]FDG uptake. MethodsIn this retrospective study, a total of 564 patients with pulmonary lesions who underwent 2-[18F]FDG positron emission tomography/computed tomography (PET/CT) examination were analyzed. The maximum standard uptake value (SUVmax) of the proximal (pSUVmax) and distal (dSUVmax) regions of the lesions were measured, respectively. Then, Q-FMSD was obtained by the ratio of pSUVmax to dSUVmax. The diagnostic performance and area under receiver operating characteristic curve (AUC) were compared between Q-FMSD and conventional PET/CT methods for the diagnosis of pulmonary lesions with high 2-[18F]FDG uptake. ResultsThe malignant tumors presented significantly higher Q-FMSD values than the benign lesions (1.11 vs. 0.94, P
ISSN:2223-4292
2223-4306
DOI:10.21037/qims-21-1148