Animal models - Mimicking the pain of trigeminal neuralgia

Trigeminal neuralgia (TN) is an episodic facial pain which feels like an electric shock of unilateral origin. This neuropathic disorder is an intensely stressful to bear for patient and impacts the quality of life. Most of the cases of TN arise when the root of fifth cranial nerve, i.e., trigeminal...

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Bibliographic Details
Published in:Indian journal of pharmacology 2022-03, Vol.54 (2), p.138-145
Main Authors: Gupta, Sonu, Bansal, Ravinder, Singh Sodhi, Surender, Brar, Gursimrat
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Facial Pain - diagnosis
Humans
Laboratory animals
Mechanical properties
Models, Animal
Neuralgia, Trigeminal
Pain
Pharmacology
Physiological aspects
Physiological research
Quality of Life
Review
Trigeminal Nerve
Trigeminal Neuralgia - diagnosis
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Summary:Trigeminal neuralgia (TN) is an episodic facial pain which feels like an electric shock of unilateral origin. This neuropathic disorder is an intensely stressful to bear for patient and impacts the quality of life. Most of the cases of TN arise when the root of fifth cranial nerve, i.e., trigeminal nerve is compressed after a few millimeters of its entry into the pons. This article describes various animal models and the role of biomarkers to study the underlying mechanisms of neuropathic pain in animal models as well as different modes of management of TN.
ISSN:0253-7613
1998-3751
DOI:10.4103/ijp.ijp_296_19