Trafficking in blood vessel development

Blood vessels demonstrate a multitude of complex signaling programs that work in concert to produce functional vasculature networks during development. A known, but less widely studied, area of endothelial cell regulation is vesicular trafficking, also termed sorting. After moving through the Golgi...

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Bibliographic Details
Published in:Angiogenesis (London) 2022-08, Vol.25 (3), p.291-305
Main Authors: Francis, Caitlin R., Kushner, Erich J.
Format: Article
Language:English
Subjects:
Angiogenesis
Biology
Biomedical and Life Sciences
Biomedicine
Blood vessels
Cancer Research
Cardiology
Cell Biology
Endothelial cells
Golgi apparatus
Ligands
Motility
Oncology
Ophthalmology
Organelles
Protein transport
Proteins
Regulation
Review Paper
Vascular endothelial growth factor
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Summary:Blood vessels demonstrate a multitude of complex signaling programs that work in concert to produce functional vasculature networks during development. A known, but less widely studied, area of endothelial cell regulation is vesicular trafficking, also termed sorting. After moving through the Golgi apparatus, proteins are shuttled to organelles, plugged into membranes, recycled, or degraded depending on the internal and extrinsic cues. A snapshot of these protein-sorting systems can be viewed as a trafficking signature that is not only unique to endothelial tissue, but critically important for blood vessel form and function. In this review, we will cover how vesicular trafficking impacts various aspects of angiogenesis, such as sprouting, lumen formation, vessel stabilization, and secretion, emphasizing the role of Rab GTPase family members and their various effectors.
ISSN:0969-6970
1573-7209
DOI:10.1007/s10456-022-09838-5