Seeking heterocyclic scaffolds as antivirals against dengue virus

Dengue is one of the most typical viral infection categorized in the Neglected Tropical Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and majorly puts risk to the lives of more than half of the world. Recent advancements in medicinal chemistry have led to the des...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2022-10, Vol.240, p.114576-114576, Article 114576
Main Authors: De, Soumik, Aamna, Bari, Sahu, Raghaba, Parida, Sagarika, Behera, Santosh Kumar, Dan, Aritra Kumar
Format: Article
Language:English
Subjects:
Aedes
Animals
Antiviral Agents - pharmacology
Antiviral medication
Dengue Virus
Female
Heterocyclic scaffolds
Humans
Neglected tropical diseases
Nitrogen
Oxygen
Structure-activity relationship
Surface activity
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Summary:Dengue is one of the most typical viral infection categorized in the Neglected Tropical Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and majorly puts risk to the lives of more than half of the world. Recent advancements in medicinal chemistry have led to the design and development of numerous potential heterocyclic scaffolds as antiviral drug candidates for the inhibition of the dengue virus (DENV). Thus, in this review, we have discussed the significance of inhibitory and antiviral activities of nitrogen, oxygen, and mixed (nitrogen-sulfur and nitrogen-oxygen) heterocyclic scaffolds that are published in the last seven years (2016–2022). Furthermore, we have also discussed the probable mechanisms of action and the diverse structure-activity relationships (SARs) of the heterocyclic scaffolds. In addition, this review has elaborately outlined the mechanism of viral infection and the life cycle of DENV in the host cells. The wide set of heterocycles and their SARs will aid in the development of pharmaceuticals that will allow the researchers to synthesize the promising anti-dengue drug candidate in the future. [Display omitted] •Dengue is a critical viral infection under Neglected Tropical Diseases.•The molecular mechanism and life cycle of DENV infection have been elucidated.•The inhibitory effect of several heterocyclic Scaffolds on DENV has been outlined.•SAR of heterocycles on the DENV serotypes has been summarized.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2022.114576