Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC

ZC3H12C is an important member of the CCCH-zinc finger protein family and is mainly involved in host immune and inflammatory diseases. However, its abnormal expression and prognostic value in cancer have not yet been established. Through comparative analysis of the Cancer Genome Atlas (TCGA) databas...

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Bibliographic Details
Published in:BioMed research international 2022, Vol.2022 (1), p.4541571-4541571
Main Authors: Yue, Yanping, Wu, Yumeng, Zhao, Dakun, Wu, Biao, Wu, Xuming, Liu, Jibin, Yang, Lei, Shen, Aiguo
Format: Article
Language:English
Subjects:
Binding proteins
Biomarkers
Cancer
Carcinoma, Renal cell
Care and treatment
Comparative analysis
Datasets
DNA methylation
Gene expression
Genetic aspects
Genomes
Health aspects
Immunology
Immunotherapy
Inflammatory diseases
Kidney cancer
Lymphocytes
Medical prognosis
Monocytes
Oncology, Experimental
Patient outcomes
Patients
Phosphorylation
Prognosis
Protein expression
Proteins
Renal cell carcinoma
Therapeutic targets
Tumors
Visualization
Zinc finger proteins
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Summary:ZC3H12C is an important member of the CCCH-zinc finger protein family and is mainly involved in host immune and inflammatory diseases. However, its abnormal expression and prognostic value in cancer have not yet been established. Through comparative analysis of the Cancer Genome Atlas (TCGA) database, we found that ZC3H12C is the most relevant to the prognosis, grade, and stage of renal clear cell carcinoma (ccRCC) across 33 cancers. With the help of patient transcription and clinical data from the TCGA and GEO (GSE53757, GSE36895) databases, we determined that in the immune environment of patients with ccRCC, ZC3H12C was clearly negatively correlated with Tregs and was significantly positively correlated with monocytes. In addition, protein phosphorylation and DNA methylation analysis also showed that ZC3H12C negatively regulates the role of cancer in ccRCC. Our research may provide new insights into ccRCC immunotherapy and bring forth novel biomarkers and therapeutic targets.
ISSN:2314-6133
2314-6141
DOI:10.1155/2022/4541571