A simple specimen preparation method for histopathological evaluation of vestibular organs

Vestibular organs consist of the maculae staticae, which are located in both the utricle and saccule, as well as the semicircular ducts and their ampullas. There have been no reports on specimen preparation methods for vestibular organs, including maculae staticae or semicircular ducts. In this stud...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Toxicologic Pathology 2022, Vol.35(3), pp.275-279
Main Authors: Onishi, Shinichi, Murai, Atsuko, Kito, Aki, Kawashima, Yuka, Ohmori, Yusuke, Kato, Atsuhiko
Format: Article
Language:English
Subjects:
Ducts
Genetic modification
maculae staticae
mice
Organs
Otoliths
Saccule
semicircular ducts
Specimen preparation
Toxicity
Utricle
vestibular organs
Vestibular system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vestibular organs consist of the maculae staticae, which are located in both the utricle and saccule, as well as the semicircular ducts and their ampullas. There have been no reports on specimen preparation methods for vestibular organs, including maculae staticae or semicircular ducts. In this study, we investigated highly reproducible methods of preparing vestibular organ specimens for histopathological examinations. We established a method that allows researchers to observe the utricle and saccule, including otoliths, the ampulla of a semicircular duct, and parts of semicircular ducts. This highly reproducible method is useful for histopathological analysis of mice with symptoms of abnormal equilibrium caused by medical toxicity and genetic modification.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.2022-0008