Regulation of the lysosome by sphingolipids: potential role in aging

Sphingolipids are a class of bioactive complex lipids that have been closely associated with aging and aging-related diseases. However, the mechanism through which sphingolipids control aging has long been a mystery. Emerging studies reveal that sphingolipids exert tight control over lysosomal homeo...

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Bibliographic Details
Published in:The Journal of biological chemistry 2022-07, Vol.298 (7), p.102118-102118, Article 102118
Main Authors: Tang, Haiqing, Huang, Xiaokun, Pang, Shanshan
Format: Article
Language:English
Subjects:
aging
JBC Reviews
lifespan
lysosomal calcium
lysosomal cell death
lysosome
lysosome-mitochondria communication
mTOR
sphingolipid
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Summary:Sphingolipids are a class of bioactive complex lipids that have been closely associated with aging and aging-related diseases. However, the mechanism through which sphingolipids control aging has long been a mystery. Emerging studies reveal that sphingolipids exert tight control over lysosomal homeostasis and function, as evidenced by sphingolipid-related diseases, including but not limited to lysosomal storage disorders. These diseases are defined by primary lysosomal defects and a few secondary defects such as mitochondrial dysfunction. Intriguingly, recent research indicates that the majority of these defects are also associated with aging, implying that sphingolipid-related diseases and aging may share common mechanisms. We propose that the lysosome is a pivotal hub for sphingolipid-mediated aging regulation. This review discusses the critical roles of sphingolipid metabolism in regulating various lysosomal functions, with an emphasis on how such regulation may contribute to aging and aging-related diseases.
ISSN:0021-9258
1083-351X
DOI:10.1016/j.jbc.2022.102118