Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case-control study

To determine whether body size in different age periods is associated with an increased risk of MS in Saudi Arabia. This study included 307 MS patients and 307 healthy controls from clinics and hospital wards in three cities (Riyadh, Jeddah, and Dammam) in Saudi Arabia (2016-2017). We used Stunkard&...

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Bibliographic Details
Published in:Neurosciences (Riyadh, Saudi Arabia) Saudi Arabia), 2022-04, Vol.27 (2), p.87-93
Main Authors: Al-Wutayd, Osama A, Mohamed, Ashri G, Saeedi, Jameelah A, Alotaibi, Hessa S, Al Jumah, Mohammed A
Format: Article
Language:English
Subjects:
Adolescent
Analysis
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Male
Medical research
Medicine, Experimental
Multiple Sclerosis
Obesity
Obesity - epidemiology
Original
Risk Factors
Saudi Arabia - epidemiology
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Summary:To determine whether body size in different age periods is associated with an increased risk of MS in Saudi Arabia. This study included 307 MS patients and 307 healthy controls from clinics and hospital wards in three cities (Riyadh, Jeddah, and Dammam) in Saudi Arabia (2016-2017). We used Stunkard's standard body silhouettes to determine the participants' body sizes (from 1 to 9) during different age periods (school levels). We calculated adjusted odds ratios (AORs) and 95% confidence intervals (CIs) and performed multivariable analysis adjusted for age and gender. Large body sizes (silhouettes 6-9) and body size 5 during intermediate school were associated with an increased risk of MS (AOR: 3.75, 95% CI: 1.10-12.78 and AOR: 3.75, 95% CI: 1.41-10, respectively). The smallest body size (1) during intermediate school was associated with a lower risk of MS (AOR: 0.39, 95% CI: 0.17-0.90) compared to body size 3. Overweight and obesity during the intermediate school period (ages 13-15 years) are associated with an increased risk of MS, particularly among females.
ISSN:1319-6138
1319-6138
DOI:10.17712/nsj.2022.2.20210121