Prevalence of nonalcoholic fatty liver disease and its association with age in patients with type 2 diabetes mellitus

• Published in: World journal of hepatology 2022-06, Vol.14 (6), p.1226-1234
• Main Authors: Yamane, Ryosuke, Yoshioka, Kentaro, Hayashi, Kazuhiko, Shimizu, Yuko, Ito, Yuki, Matsushita, Komei, Yoshizaki, Michiyo, Kajikawa, Go, Mizutani, Taro, Watarai, Atsuko, Tachi, Kosuke, Goto, Hidemi
• Format: Article
• Language: English
• Subjects: Observational Study
• ISSN: 1948-5182; 1948-5182
• DOI: 10.4254/wjh.v14.i6.1226

BACKGROUNDType 2 diabetes mellitus (T2DM) is a risk factor for nonalcoholic fatty liver disease (NAFLD). AIMTo determine the prevalence and clinical correlates of NAFLD in a large cohort of patients with T2DM. METHODSFour hundred thirty-seven participants with T2DM who consulted at Meijo Hospital from April 2019 to September 2020 and underwent computed tomography (CT) were assessed. The mean age was 74 ± 13 years, and 269 were men. Hepatic attenuation minus splenic attenuation (CTL-S) less than 1 Hounsfield unit was considered fatty liver. NAFLD was defined as fatty liver in the absence of significant alcohol consumption and hepatitis virus infection. A multiple logistic regression was used to assess the independent factors associated with NAFLD. RESULTSNAFLD was identified in 25.2% of the participants. Young age (odds ratio [OR] = -0.945; 95% confidence interval [CI]: 0.922-0.969), higher hemoglobin levels (OR = 1.501, 95%CI: 1.278-1.764), lower high-density lipoprotein (HDL) cholesterol levels (OR = 0.971, 95%CI: 0.953-0.989), and the absence of dialysis (OR = 0.109, 95%CI: 0.014-0.856) were independent predictors of NAFLD. CONCLUSIONNAFLD was detected with CT in 25.2% of the participants. NAFLD was associated with younger age, higher hemoglobin levels, lower HDL cholesterol levels, and an absence of dialysis.