Routine use of FLAIR-negative MRI in the treatment of unknown onset stroke

Treatment of FLAIR-negative stroke in patients presenting in an unknown time window has been shown to be safe and effective. However, implementation can be challenging due to the need for hyper-acute MRI screening. The purpose of this study was to review the routine application of this practice outs...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2020-09, Vol.29 (9), p.105093-105093, Article 105093
Main Authors: Adil, Malik M., Luby, Marie, Lynch, John K., Hsia, Amie W., Kalaria, Chandni P., Nadareishvili, Zurab, Latour, Lawrence L., Leigh, Richard
Format: Article
Language:English
Subjects:
FLAIR negative
MRI
Thrombolysis
Unknown onset
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Summary:Treatment of FLAIR-negative stroke in patients presenting in an unknown time window has been shown to be safe and effective. However, implementation can be challenging due to the need for hyper-acute MRI screening. The purpose of this study was to review the routine application of this practice outside of a clinical trial. Patients presenting from 3/1/16 to 8/22/18 in a time window 4.5 h from last known normal were included if they had a hyper-acute MRI performed. Quantitative assessment based on the MR WITNESS trial and qualitative assessment based on the WAKE-UP trial were used to grade the FLAIR images. The MR WITNESS trial used a quantitative assessment of FLAIR change where the fractional increase in signal change had to be
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2020.105093